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Scientific Basis of Adjuvant Chemotherapy in Breast
F Rajewsky and N
G Bonadonna and P Valagussa
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5-fluorouracil adjuvant chemotherapy adjuvant therapy adjuvant treatment adriamycin analysis axillary lymph nodes Bonadonna G Buzdar CALGB Cancer Res Cancer Research Clin Oncol clinical trials CMFP CMFPT CMFVP Combination chemotherapy compared control group cycles cyclophosphamide difference disease-free survival dose doxorubicin drug ECOG evaluable patients Fisher Grune and Stratton Hazard ratio Heidelberg 1984 irradiation Jones SE eds l-PAM leukemia malignant median follow-up melphalan menopausal menopausal status metastases methotrexate micrometastases Milan months NHDB node-negative node-positive nodes involved NSABP number of patients observed Oncology Group operable breast cancer overall survival patients treated positive nodes postmenopausal postmenopausal patients postoperative prednisone premenopausal patients primary breast cancer primary tumor progesterone receptor prognostic factors protocol radiotherapy randomized Recent Results recurrence regimens relapse relapse-free survival reported Results in Cancer Salmon significant significantly stage II breast subgroups subsets surgery Table tamoxifen therapy of cancer toxicity tumor cells Valagussa