Adult Neurogenesis and Neural Stem Cells in Mammals

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Nova Publishers, 2006 - Medical - 208 pages
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This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.
 

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Contents

Neurogenesis in the Adult Mammalian Brain
1
Neural Stem Cells
21
Cellular and Molecular Mechanisms of Adult Neurogenesis
35
Modulation of Neurogenesis in the Adult Brain
53
Broader Potential of Adult Stem Cells
65
Neurogenesis in Neurodegenerative and Neurological Diseases
77
Neurogenesis in Ischemic Strokes
97
Neurogenesis in Traumatic Brain Injury
109
Adult Retinal Stem Cells
125
Adult Neurogenesis and Regeneration Repairing and Healing the CNS
131
Adult Neurogenesis and Neuroplasticity
145
Adult Neurogenesis and Neuroadaptation
151
Cancer Stem Cells and Brain Tumor Stem Cells
165
Cellular Therapy in the Central Nervous System
175
Conclusion and Perspectives
195
Index
197

Stem Cells in the Adult and Injured Spinal Cord
115

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Page vii - J. (1969). Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J.

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