Adult Stem Cell Standardization

Front Cover
Paolo Di Nardo
River Publishers, 2011 - Medical - 260 pages
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Stem cell research and technology represent a major challenge for treating otherwise non-curable patients. A decade of intensive research has demonstrated that initial hopes based more on the will to succeed than on solid scientific bases can be translated into factual techniques only by adopting more rigorous procedures and strategies. Among other major impediments, the failure so far experienced in applying stem cell technologies to repair parenchymal organs can be ascribed to the lack of sufficient knowledge of basic mechanisms but also to the lack of standardized criteria and protocols. Each laboratory often follows its own "recipe," using erratic nomenclature and non-comparable, if not confusing, experimental protocols. All of this makes it difficult to learn from the others and, ultimately, hampers the advancement of knowledge on stem cell behavior.

The ambitious goal of this book is to gather the most innovative and scientifically robust knowledge and technologies on stem cells and to involve investigators from academies and industries in order to formulate recommendations that could standardize the isolation and manipulation of stem cells using solid and well-documented knowledge rather than fragmentary and often unrepeatable experimental reports.
 

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Contents

A Perspective in Myocardial Tissue Restoring
1
Should Viral Uninfectibility Be an Additional Required
9
Recent Results on Human Bone Marrow Mesenchymal Stem Cell
31
Molecular Characterization of Stem Cells in Breast Cancer
41
Foreign Body Response to Subcutaneously Implanted Scaffolds
55
The Ethics of Stem Cell Research Publication
63
Stem Cell Delivery into the Myocardial Wall
99
The Role of Stem Cells
127
Design of a Biomimetic Niche for Adult Progenitor Cell
149
Aging of Human BoneDerived Mesenchymal Stem Cells
167
Current View and Future Outlook
183
AdiposeDerived Stem Cells as Source for Tissue Repair
191
Embryonic Stem Cells in Cardiac Regeneration
209
A Case Study
223
Author Index
239
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