Advanced Analysis of Gene Expression Microarray Data

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World Scientific, 2006 - Science - 339 pages
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This book focuses on the development and application of the latest advanced data mining, machine learning, and visualization techniques for the identification of interesting, significant, and novel patterns in gene expression microarray data.Biomedical researchers will find this book invaluable for learning the cutting-edge methods for analyzing gene expression microarray data. Specifically, the coverage includes the following state-of-the-art methods: • Gene-based analysis: the latest novel clustering algorithms to identify co-expressed genes and coherent patterns in gene expression microarray data sets• Sample-based analysis: supervised and unsupervised methods for the reduction of the gene dimensionality to select significant genes. A series of approaches to disease classification and discovery are also described• Pattern-based analysis: methods for ascertaining the relationship between (subsets of) genes and (subsets of) samples. Various novel pattern-based clustering algorithms to find the coherent patterns embedded in the sub-attribute spaces are discussed• Visualization tools: various methods for gene expression data visualization. The visualization process is intended to transform the gene expression data set from high-dimensional space into a more easily understood two- or three-dimensional space
 

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Contents

Introduction
1
Basic Concepts of Molecular Biology
13
Overview of Microarray Experiments
31
Analysis of DifferentiallyExpressed Genes
51
GeneBased Analysis
83
SampleBased Analysis
141
PatternBased Analysis
195
Visualization of Microarray Data
239
New Trends in Mining Gene Expression Microarray Data
285
Conclusion
305
Index
331
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