Advanced Imaging in Biology and Medicine: Technology, Software Environments, Applications

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Ch.W. Sensen, Benedikt Hallgrimsson
Springer Science & Business Media, Dec 3, 2008 - Medical - 445 pages
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A picture says more than a thousand words. This is something that we all know to be true. Imaging has been important since the early days of medicine and bi- ogy, as seen in the anatomical studies of Leonardo Da Vinci or Andreas Vesalius. More than 100 years ago, the ?rst noninvasive imaging technologies, such as K- rad Roentgen’s X-ray technology,were applied to the medical ?eld—and while still crude—revolutionized medical diagnosis. Today, every patient will be exposed to some kind of advanced imaging technology such as medical resonance imaging, computed tomography or four-dimensional ultrasound during their lifetime. Many diseases, such as brain tumors, are initially diagnosed solely by imaging, and most of the surgical planning relies on the patient imagery. 4D ultrasound is available to expecting parents who wish to create unique early memories of the new baby, and it may soon be used for the morphometric diagnosis of malformations that may one day be treatable—inutero! Light and electron microscopy are unequal brethren, which have contributed to most of our knowledge about the existence and organization of cells, tissues and microorganisms. Every student of biology or medicine is introduced to the fascinating images of the microcosm. New advances have converted these im- ing technologies, which were considered by many to be antiquated, into powerful tools for research in systems biology and related ?elds.
 

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Contents

MicroComputed Tomography
3
Advanced Experimental Magnetic Resonance Imaging
27
Freehand 3D Ultrasound Calibration A Review
47
Laser Scanning 3D Analysis of Biological Surfaces
85
Optical Coherence Tomography Technique and Applications
102
Mass SpectrometryBased Tissue Imaging
131
Imaging and Evaluating Live Tissues at the Microscopic Level
147
Ultrastructure Imaging Imaging and Probing the Structure and Molecular MakeUp of Cells and Tissues
171
Surface Modeling
271
CAVEman An ObjectOriented Model of the Human Body
289
ImageBased Finite Element Analysis
301
Geometric Morphometrics and the Study of Development
319
Imaging in Audiology
338
Applications of Molecular Imaging with MR
363
Genomic Data Visualization The Bluejay System
394
Anatomical Imaging and PostGenomic Biology
411

Optical Projection Tomography
199
Medical Imaging Modalities An Introduction
225
Volume Visualization Using Virtual Reality Medical Applications of Volume Rendering in Immersive Virtual Environments
256
Functional Measures of Therapy Based on Radiological Imaging
427
Index
439
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About the author (2008)

Christoph W. Sensen studied Biology at the Universities of Mainz, Dusseldorf and Koln Germany. After completing post-doctoral work at the European Molecular Biological Laboratory (EMBL) in Heidelberg he joined the Institute for Marine Biosciences (National Research Council), Canada in 1994. From 1997 to 2001 Christoph Sensen was appointed Project Manager at the Canadian Bioinformatics Resource (CBR-RBC) and took up a full professorship at the University of Calgary, Department of Biochemistry & Molecular Biology in 2001. Christoph Sensen has authored numerous scientific papers and edited two books for Wiley.
HONORS AND AWARDS:
1998 NRC Corporate Outstanding Achievement Award for the Outstanding Contribution to the Canadian Bioinformatics Resource Team
2002 Fellow of the International Faculty, International Graduate School in Bioinformatics and Genome Research
2003 Computerworld Honors Award
2003 The Duke's Choice Award for Coolest Java Applications and Products at JavaOne 2003

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