Advanced Topics in Forensic DNA Typing: Methodology

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Academic Press, 2011 - Law - 680 pages
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Intended as a companion to the Fundamentals of Forensic DNA Typing volume published in 2009, Advanced Topics in Forensic DNA Typing: Methodology contains 18 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field and citation to more than 2800 articles and internet resources. The book builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience.  This book provides the most detailed information written to-date on DNA databases, low-level DNA, validation, and numerous other topics including a new chapter on legal aspects of DNA testing to prepare scientists for expert witness testimony. Over half of the content is new compared to previous editions. A forthcoming companion volume will cover interpretation issues.

  • Contains the latest information - hot-topics and new technologies
  • Well edited, attractively laid out, and makes productive use of its four-color format
  • Author John Butler is ranked as the number one "high-impact author in legal medicine and forensic science, 2001 to 2011" by ScienceWatch.com
 

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Contents

Chapter 1 Sample Collection Storage and Characterization
1
Chapter 2 DNA Extraction Methods
29
Chapter 3 DNA Quantitation
49
Capabilities and Cautions
69
Chapter 5 Short Tandem Repeat STR Loci and Kits
99
Principles and Instrumentation
141
Chapter 7 Quality Assurance and Validation
167
Uses and Issues
213
Chapter 13 YChromosome DNA Testing
371
Chapter 14 Mitochondrial DNA Analysis
405
Chapter 15 XChromosome Analysis
457
Chapter 16 Nonhuman DNA
473
Chapter 17 New Technologies and Automation
497
Chapter 18 Legal Aspects of DNA Testing and the Scientific Expert in Court
515
Appendix 1 Reported Sizes and Sequences of STR Alleles
549
Potential Pitfalls and Privacy Concerns
603

Chapter 9 Missing Persons and Disaster Victim Identification Efforts
271
Chapter 10 Degraded DNA
293
Issues Concerns and Solutions
311
Chapter 12 Single Nucleotide Polymorphisms and Applications
347
Appendix 3 List of Suppliers for DNA Instruments Reagents Services
611
Appendix 4 Interviews Supporting Legal Aspects of DNA Testing
619
Subject Index
659
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About the author (2011)

John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch's #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit http://www.cstl.nist.gov/strbase/butler.htm.

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