Advanced Genetic Analysis: Genes, Genomes, and Networks in Eukaryotes
How can we explore gene expression in time and space? How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? Advanced Genetic Analysis probes fascinating questions such as these by asking "How can the principles of genetics be used as analytical tools to solve biological problems?" With its unique integration of genetics and molecular biology, Advanced Genetic Analysis provides a broad survey of how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles and model organisms, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity, before considering the interaction of genes during suppression and epistasis, and how we study gene networks. Drawing on the latest experimental tools, including microarrays, RNAi, and bioinformatics approaches, Advanced Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research without losing clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Advanced Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding. Online Resource Centre The Online Resource Centre to accompany Advanced Genetic Analysis features the following resources for instructors and students. For instructors: Figures from the book in electronic format, ready to download. Journal club: suggested papers and discussion questions linked to topics covered in the book. For students: Hyperlinked bibliography, giving quicker access to literature related to the text. Guided tours of key websites, with associated tutorials/activities. Topical updates: key updates on topics or tools presented in the book, to keep you up-to-date with latest developments in the field.
Genes and genomes
Model organisms and their genomes
19 other sections not shown
affect alignment amino acid Arabidopsis assays balancer chromosomes biological process candidate genes cDNA cells cloned gene database deletion described in Chapter detected different genes DNA sequence dominant double mutant Drosophila elegans embryo encodes epistasis eukaryotes example exon expression pattern flies function gene activity gene disruptions gene expression gene of interest gene product genetic analysis geneticists genome genome-wide screens genotype heterozygotes heterozygous homologous homozygous human hybridization hypomorphic identified inferred insertion interactions investigator involved known larval markers melanogaster methods mice microarray model organisms molecular mouse mRNA muta mutagen mutant alleles mutant phenotype mutant screens normal orthologs panel patched pathway plasmid predicted probe produce protein recessive recombination regulatory region reporter gene reverse genetics RNAi segment shown in Figure similar specific splicing strain strategy Study Figure suppressor synthetic enhancement targeted gene temperature Text Box tion tissues transcription factor transposable element TUB2 Wieschaus wild-type wing worms yeast