Advanced organic chemistry of nucleic acids
Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.
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Structure of Nucleosides
Structure of Nucleotides
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5-phosphate acyl adenine adenosine alkyl amino group analysis anhydrides base pairs carbohydrate moiety carboxylic chemical cleavage cleaved cloning codons coli complementary complex compounds corresponding cyclic phosphate cytidine cytosine denaturation derivatives determined DNA fragments double-stranded duplex electrophoresis enzymatic enzyme esters example formation gene glycosidic glycosidic bond guanine guanosine heterocyclic heterocyclic bases HOCH2 hydrogen hydrolysis hydroxyl hydroxyl group interactions internucleotide linkages involved labeled ligation method methyl mixture modification molecular molecule monomer monomer units N-glycosidic bonds nitrogen nucleic acids nucleo nucleophilic substitution nucleotide nucleotide component nucleotide sequence OH OH oligo oligonucleotides oxidation pH values phage phate phos phosphate group phosphorus phosphorus atom polymer polynucleotide polynucleotide chain presence primary structure protein proton purine purine bases pyrimidine pyrimidine and purine pyrimidyl reaction reactivity reagents result ribonucleoside ribose ribozyme ring RNase secondary structure segments single-stranded stable strands synthesis synthetic tertiary structure thymine tion tRNA uracil uridine vector yield