Advances in Blood Substitutes: Industrial Opportunities and Medical Challenges

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Springer Science & Business Media, Sep 23, 1997 - Medical - 336 pages
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Each chapter of this volume is a contribution from an expert in the field, chosen by the editors to contribute to the 1997 "Current Issues in Blood Substitute Research and Development" course given in San Diego, March 17-19. The contributors were selected because of their expertise in areas which the editors believe to be critical to the advancement of the field, and which reflect activity in "hot" areas of relevant research. While there is a continuity in style for the annual course, each year brings changes in emphasis and content. In previous years, we were often not able to provide time for participants to present their views and opinions. Consequently, this year we encouraged discussion after each presentation. These sessions were recorded, transcribed, and are printed with the chapters herein. We believe that the product is very close to the capturing this year's course in print, and trust readers will enjoy reading the always candid and often provocative remarks from the audience. The price paid for inclusion of the discussion transcriptions was a delay in publication. Each author was allowed to edit his/her discussion section as well as the final version of the chapters prior to publication. The changes are mainly for grammar, and we tried, when possible, not to alter the conversational style of these interchanges.
 

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Contents

Blood Substitutes 1996 in the Literature
1
Blood Substitutes and the Intestinal Microcirculation Extravasation and Ultrastructural Alterations
19
A Discussion of Pharmacoeconomics Applied to Blood Substitutes
38
Tumor Microcirculation Role in Drug and Nutrient Delivery
46
The Pressor Effect of HemoglobinGood or Bad?
71
Perflubronbased Emulsion Efficacy as Temporary Oxygen Carrier
91
The Other Blood Substitute Antigenically Inert Erythrocytes
133
Hemoglobin Encapsulation With Polyethylene Glycolmodified and Unmodified Vesicles Systemic and Microvascular Hemodynamics at 80 Blood Su...
151
Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes
167
The Mechanism of Tissue Oxygenation and the Design of Oxygen Carrying Plasma Expanders
189
Colloid Osmotic Effects of Hemoglobinbased Oxygen Carriers
207
Chapter 12 DextranHemoglobin
233
Modification of Molecules and Particles With Polyethylene Glycol PEG Longcirculating Pharmaceuticals
251
The Reaction of Nitric Oxide with Cellfree Hemoglobin Based Oxygen Carriers Physiological Implications
298
Index
328
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