Advances in Cholesterol Research
Advances in Cholesterol Research presents a range of topics which, for the most part, have not been reviewed in recent years in books published on cholesterol. The subject area can be divided into two main sections. The intracellular and extracellular dynamics of cholesterol. The intracellular dynamics of cholesterol includes the intracellular distributions of cholesterol, cellular functions of the sterol, cholesterol metabolism in steroidogenic tissues, the cholestryl ester cycle, relation between cholesterol and dolichol biosynthesis, and the role of cholesterol in tumor cell proliferation. The section on extracellular dynamics of cholesterol includes the biogenesis of high density lipoprotein subclasses, structure-function relation in lecithin: cholesterol acyltransferase, and the role of cholesterol in atherosclerosis and in membrane fusion.
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Transmembrane Cholesterol Distribution
The Biosynthesis of Dolichol and Its Relation
Role of Cholesterol in Cellular Functions
Lipoprotein and Cholesterol Metabolism
Intracellular Cholesteryl Ester Hydrolysis
The Role of the Cholesterol Synthesis Pathway
Conversions in the Origins and Metabolism
Modulation of Membrane Fusion
Role of Cholesterol in Atherosclerosis
Acad ACAT ACAT activity Acta acyl acyltransferase apo A-I apolipoprotein arterial atherosclerosis bilayer Biochem Biochemistry Biol Biophys cellular Chem cholesterogenesis cholesterol content cholesterol synthesis cholesteryl ester cholesteryl ester hydrolase citrate Clin conversion cultured dolichol dolichol synthesis dolichyl phosphate effect enzyme ergosterol esterification factors fatty acids fibroblasts fluorescent free cholesterol function fusion Goldstein HDL particles HDL3 hepatic high density lipoproteins HMG-CoA reductase HMGR hormones human plasma hydrolysis hypercholesterolemia increase incubation inhibition inhibitor intracellular isoprenylated J. F. Strauss Kandutsch LCAT leaflet levels Lipid Res lipid transfer liposomes low density lipoproteins lysosomal macrophages membrane cholesterol metabolism mevalonate microsomes mitochondria mitochondrial molecular molecules Natl Nemecz Nichols normal pathway phospholipid phosphorylation plasma membrane pool precursor presence Proc protein rat liver receptor regulation residues role Schroeder sequence serum specific steroid steroidogenesis steroidogenic cells sterol ester structure studies subpopulation substrate tion tissues triglyceride tumor uptake vesicles vitro VLDL w/o AII