Advances in Fungal Biotechnology for Industry, Agriculture, and Medicine

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Jan S. Tkacz, Lene Lange
Springer Science & Business Media, 2004 - Biography & Autobiography - 445 pages
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In the past half century, filamentous fungi have grown in commercial importance not only in the food industry but also as sources of pharmaceutical agents for the treatment of infectious and metabolic diseases and of specialty proteins and enzymes used to process foods, fortify detergents, and perform biotransformations. The commercial impact of molds is also measured on a negative scale since some of these organisms are significant as pathogens of crop plants, agents of food spoilage, and sources of toxic and carcinogenic compounds. Recent advances in the molecular genetics of filamentous fungi are finding increased application in the pharmaceutical, agricultural, and enzyme industries, and this trend promises to continue as the genomics of fungi is explored and new techniques to speed genetic manipulation become available.

This volume focuses on the filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.

 

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Contents

Practical Molecular Taxonomy of Fungi
3
Genomics of Filamentous Fungi
15
Gene Complement of a Filamentous Fungus
21
Summary
27
Gene Cloning Tools for Genomic Approaches
32
Transformation Mediated by Agrobacterium tumefaciens
41
Concluding Remarks
57
Fungal Polyketide Synthases in the Information
69
Heterologous Expression and Protein Secretion
201
Artificial Evolution of Fungal Proteins
221
Biocatalysis and Biotransformation
237
12
244
Lipases Triacylglycerol Hydrolases EC 3 1 1 3
253
14
262
Inactivation of Fungal Biocontrol Agents
263
Organic Acid Production by Filamentous Fungi
307

Fungal PKS
75
Novel Methods for Accessing PKS Genes
81
More Functions for Multifunctional Polyketide Synthases
97
Concluding Remarks
118
Peptide Synthesis Without Ribosomes
127
Parsing Fungal NRP Synthetases
136
Regulation
142
Evolution of NRPs and NRP Synthetases
151
Gene Clusters and Chemical Puzzles
163
Diterpenes
174
Tetraterpenes
184
Final Perspective
332
Other Pathogenic Filamentous Fungi
379
Molecular Interactions of Phytopathogens and Hosts
385
Genomics of Phytopathogens
399
Structural and Functional Genomics of Symbiotic Arbuscular
405
Manipulating the Symbiotic Genome
414
Index
425
364
429
371
438
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Page 428 - Lee, MG and Nurse, P. (1987). Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.

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