Advances in Genetics, Volume 35
Academic Press, Mar 21, 1997 - Science - 331 pages
Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.
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Chapter 2 Apoptosis
Chapter 3 Molecular Basis for XLinked Immunodeficiencies
Chapter 4 Gene Therapy of Duchenne Muscular Dystrophy
Chapter 5 The Contribution of the Mouse to Advances in Human Genetics
A Conditional Dominant Lethal Interaction in Drosophila
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Acad activity adenovirus alleles amino acid analysis animals apoptosis Arabidopsis awdº binding Biochem Biol biosynthesis CAB expression CAB gene CAB2 cardiac cardiomyopathy cDNA cell death chromosome circadian clock clinical cloning defect deletion disease domain Drosophila melanogaster drosopterin Duchenne muscular dystrophy dystrophin encodes enzyme exon fibers function gene expression gene transfer Genet genome HIGM homologous homozygous human identified Immunol injection interaction interleukin Kerr Killer of prune lethal linkage loci locus lymphocytes meiosis meiotic mice molecular mouse genome mRNA muscular dystrophy mutations myoblasts Natl NDP kinase normal Notarangelo pathways patients phenotype photoreceptor phytochrome plants Proc protein Prune eyes prune mutants prune/Killer of prune pteridine receptor recombination region regulation role segregation sequence severe combined severe combined immunodeficiency skeletal muscle specific studies synaptonemal complex targeted tion tissues transcription transgenic vectors Vihinen vivo wild-type Wiskott-Aldrich syndrome Wyllie X-linked agammaglobulinemia XSCID yeast