Advances in Genetics, Volume 32
Academic Press, Jun 23, 1995 - Science - 322 pages
Volume 32 of Advances in Genetics: Incorporating Molecular Genetic Medicine focuses on important and fast moving subjects in modern human genetics and medicine. This volume also marks the new collaboration with Associate Editors Dr. Theodore Friedmann and Dr. Francesco Giannelli. Chapter 1 considers the potential effectiveness and consequences of gene therapy on subjects over time. Chapter 2 discusses recent research on Gaucher's disease, the first disorder to demonstrate the clinical benefits of enzyme replacement therapy. Chapter 3 describes current findings on diabetes, a disease difficult to conquer due to its variety and its genetic and environmental causes. The major forms of hemophilia and the need for alternative therapies are discussed in Chapter 4. Chapter 5 presents hypercholesterolemia as a model for understanding the causes and treatments of human diseases on a molecular level. Chapter 6 probes the basic genetic defects behind phenylketonuria, as well as the possibilities for genetic correction. Chapter 7 covers the fascinating terminal structures of human chromosomes.
In the Foreword to Volume 32, Drs. Friedmann and Giannelli suggest: "Progress toward a thorough characterization of the human genome is stunningly rapid and exceeding many of its earliest expectations. Disease-related genes will be falling from the skies faster than we can understand them, and mechanisms responsible for the pathogenesis of disease will be illuminated more quickly and readily than ever before. "With comprehensive and timely reviews, Advances in Genetics incorporating Molecular Genetic Medicine offers with every volume further insight into this expanding field of medicine, supplementing the continued expert coverage of all other areas of genetics pioneered by Advances in Genetics.
* Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment
* Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness
* Documents the revolution in human and molecular genetics leading to a new field of medicine
* Volume 32 marks new collaboration with Associate Editors Dr. Theodore Friedmann and Dr. Francesco Giannelli
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Chapter 3 The Genetics of NoninsulinDependent Diabetes Mellitus
Chapter 4 The Hemophilias
Chapter 5 The Influence of Molecular Biology on our Understanding of Lipoprotein Metabolism and the Pathobiology of Atherosclerosis ...
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Acad activity adverse experiences alleles amino acid analysis apoA-I apoB apoE apolipoprotein associated atherosclerosis Beutler binding Biol cDNA cells Chem cholesterol chromosome ends chylomicron clinical trials cloning codon Consortium deﬁciency deletion detection domain Eisensmith encoding enzyme exon expression factor IX factor VIII factor VIII gene ﬁrst frequency function Gaucher disease gene therapy Genet genotype Giannelli glucocerebrosidase glucokinase glucose Guldberg haplotype hemophilia hepatocytes homology homozygous human chromosome human PAH hybridization identiﬁed insulin receptor insulin resistance intron kinase LDL receptor levels linkage liver locus macrophages markers metabolism minisatellite molecular mouse mRNA Natl NIDDM normal PAH gene patients phenotype phenylalanine hydroxylase phenylalanine hydroxylase gene phenylketonuria plasma polymorphisms populations Proc protein proterminal regions recombination residues result role scavenger receptor signiﬁcant speciﬁc splice studies subterminal repeat telomerase telomere telomere repeat terminal tion tissue transcription TTAGGG tyrosine uptake vectors vitro vivo VLDL