Advances in Molecular Toxicology

Front Cover
Claude Reiss, Simone Parvez, Gilles Labbe
VSP, 1998 - Science - 568 pages
Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

The use of video microscopy and confocal laser scan microscopy
17
Quantitative analysis of apoptotic neuronal cell death
35
Hgh Performance Capillary Electrophoresis HPCE in molecular
53
Interactions between a cell biology unit and a cell bank
87
G Labbe
103
QSTR applications in acute chronic and developmental toxicity
141
K Enslein 141
164
Chemical carcinogenesis as a consequence of cell cycle dysregulation
177
Key events in organotin cytotoxicity
329
Primaquine cytotoxicity genotoxicity and CYP1A induction
359
Toxic effects on mammalian liver adrenal cortex and testis from
373
8Hydroxydeoxyguanosine 8Ohdg as a biomarker of carcinogenic
409
Rapid detection of nongenotoxic carcinogens of environmental
431
Strategies for gene
445
Analysis of cyto and genotoxic effects of atmospheric pollutants
467
A new bacterial RecA gene cloned from a human small intestine
481

Role of peroxisome
213
Eicosanoids as endogenous mediators of carcinogenesis and reporters
247
Relationship between photomutagenicity and photocarcinogenicity
269
Cell engineering of the human cysteine conjugate beta lyase gene
283
Behavior and carbohydrate metabolism impairments induced
313
New approaches in immunotoxicology
499
The molecular architecture of an individuals genetic susceptibility
517
Heatshock proteins in ecotoxicological risk assessment
531
Induction of heat shock proteins 7072 and inhibition of neurite
545
Copyright

Common terms and phrases

Popular passages

Page 528 - Sambrook, J., Fritsch, EF, and Maniatis, T. (1989). "Molecular Cloning: A Laboratory Manual," 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Bibliographic information