Advances in Molecular and Cellular Endocrinology, Volume 1
Elsevier, Mar 25, 1997 - Medical - 269 pages
Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.
Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and
less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.
In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.
Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.
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Chapter 2 Molecular Aspects of Hormone Deficiency Caused By PIT1 Gene Mutations
Chapter 3 Regulation of Growth Hormone Gene
Chapter 4 Molecular Aspects of the InsulinLike Growth Factor IGF Genes
Chapter 5 Molecular Aspects of InsulinLike Growth Factor Binding Proteins
Chapter 6 Molecular Basis of Insulin Action
3-kinase Acad adipocytes afﬁnity amino acids Baxter binding sites Biochem Biol Biophys calcium cDNA cell line characterization Chem cleavage Clin cloning complex contains dimerization DNA binding encoding Endocrinol Endocrinology enhancer exon extracellular factor binding protein factor-I Figure function gene expression gene transcription GH gene GHRF glucagon gene glucose transport GLUT4 GnRH GnRH gene gonadotropin-releasing hormone growth factor binding GT1 cells human insulin-like growth hypercalcemia hypothalamic identiﬁed IGF-I IGF-I gene IGFBP IGFBP-3 inhibit insulin receptor insulin-like growth factor interaction intron IRS1 levels mediated molecular motif mouse mRNA mutations Natl neurons nuclear nucleotide pancreatic parathyroid pathway peptide phosphorylation Pit-1 gene pituitary precursor Proc proglucagon prolactin promoter protein kinase protein-3 proteolysis regulation residues response elements Rosenfeld sequence serum SH2 domains signal somatostatin speciﬁc splicing stimulation structure substrate subunit tissues transcription factors transfected tyrosine kinase tyrosine phosphorylation upstream vitro vivo