Advances in Molecular and Cellular Endocrinology, Volume 1

Front Cover
D. LeRoith
Elsevier, Mar 25, 1997 - Medical - 269 pages
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Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.
Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and
less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.
In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.
Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.
 

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Contents

Chapter 2 Molecular Aspects of Hormone Deficiency Caused By PIT1 Gene Mutations
31
Chapter 3 Regulation of Growth Hormone Gene
51
Chapter 4 Molecular Aspects of the InsulinLike Growth Factor IGF Genes
83
Chapter 5 Molecular Aspects of InsulinLike Growth Factor Binding Proteins
123
Chapter 6 Molecular Basis of Insulin Action
161
Chapter 7 Molecular Aspects of the Glucagon Gene
203
Chapter 8 Molecular Aspects of Familial Hypocalciuric Hypercalcemia
229
Chapter 9 Molecular Aspects of Steroid ReceptorDna Binding
241
Index
265
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