Advances in Neuroscience and Schizophrenia
A.H. Tuma, E.M. Stricker, S. Gershon
Springer Vienna, Jul 30, 1992 - Medical - 202 pages
Schizophrenia has been the subject of intense research interest in recent years, as investigators have explored the biological bases for the disorder and for various approaches to its diagnosis and treatment. This volume focuses on three aspects of such recent research connecting basic neuroscience to schizophrenia. In one, Professors Budinger, Gur, and Pettegrew provide critical reviews of brain imaging studies as they relate to cognitive behaviour functions in schizophrenia. In the second, Professors Goldmann-Rakic, Lewis, and Tassin discuss monoamine systems and their varied role in prefontal cortical circuitry and function. In the third, Professors Deutsch, Gerfen, and Grace discuss the structure, organization, and function of the basal ganglia, as they relate to schizophrenia and the mechanisms of neuroleptic action. These papers were presented at an interdisciplinary workshop on the subject at the University of Pittsburgh, in May 1991, and the discussion between the authors and other panelists in basic and clinical sciences are included in this volume as well. The presentation of these diverse approaches in an integrated fashion provides the reader with a unique perspective and a wealth of new questions for future collaborative research.
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Critical review of PET SPECT and neuroreceptor studies in schiz
MRI and cognitive behavioral function in schizophrenia
Molecular insights into schizophrenia
9 other sections not shown
31P NMR abnormalities acid activity acute adrenergic adrenergic receptors afferents agonist amphetamine anatomical animals antipsychotic drugs Arch Gen Psychiatry autoreceptors axons basal ganglia behavioral biochemical Brain Res Bunney catecholamine cell firing cerebral cortex chronic clinical clozapine cognitive compartments cortical Dl corticostriatal decrease deficits density depolarization block Deutch disorders Dl receptors dopamine neurons dopamine receptor dopamine release dopaminergic dopaminergic neurons dorsal striatum effects excitatory fibers frontal function GABAergic Gerfen globus pallidus Glowinski glutamate Goldman-Rakic Grace AA haloperidol human increase induced injection innervation inputs interactions labeled laminar layers limbic medial membrane mesolimbic metabolism metabolites modulate monkey prefrontal cortex neocortex Neurochem neuroleptics Neurosci neurotransmitter noradrenergic normal nucleus accumbens observed pathways Pettegrew JW pharmacological phospholipid prefrontal cortex presynaptic primate projections Pycock regions regulation response schizo schizophrenia schizophrenic patients stimulation striatal striatonigral striatopallidal studies substantia nigra suggest symptoms synaptic Tassin JP terminals therapeutic tion tonic treatment ventral striatum vivo