Advances in Pharmacology, Volume 28
Academic Press, Jul 6, 1994 - Medical - 361 pages
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
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Nitric Oxide Pathway in Circulatory Shock
Scientific Background and Possible Clinical Applications
Chapter 4 Therapeutic Implications of Delivery and Expression of Foreign Genes in Hepatocytes
Chapter 5 Recombinant Toxins
Chapter 6 Therapeutic Potential of the Lazaroids 21Aminosteroids in Acute Central Nervous System Trauma Ischemia and Subarachnoid Hemorrhage
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21-aminosteroid Acad activating factor adhesion molecule affinity amino acids angiotensin II receptor antisense artery AT1 receptors attenuated azithromycin binding sites Biochem Biol Biophys blood brain Braquet Braughler cDNA cellular cerebral Chem clarithromycin Clin clinical cloning compounds cytokines cytotoxic domain dose E-selectin effect endothelial cells endothelium endotoxemia endotoxin enzyme erythromycin exotoxin expression factor antagonist function gene hemorrhagic hepatocytes human hypotension Immunol increase induced infected inflammatory inhibition inhibitor injury interleukin intracellular ischemia ischemic Kreitman L-NMMA leukocyte ligand lipid liver LPS-induced lymphocytes macrolides Mediators membrane mg/kg mice monoclonal antibody mRNA Natl neutrophils nitric oxide synthase oligonucleotides PAF antagonists PAF receptor antagonists PAF-induced Pastan patients peroxidation Pharmacol pharmacological phospholipase plasma platelet platelet-activating factor Proc protein rabbit radical receptor antagonists recombinant toxins reduced release reperfusion role septic shock smooth muscle studies subtypes synthesis target tirilazad tirilazad mesylate tissue tumor vitro vivo