Advances in Protein Chemistry and Structural Biology, Volume 79
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
*Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
* Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
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Sequences Structures Evolution and Functions
From Inclusion Bodies to Amyloid and Biomaterials
From Neurodegeneration to Industrial Biotechnology
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Acad activity Ada2 Ada3 amino acid amyloid fibrils associated ataxin-7 ATXN7 protein base pair Biochem Biol BLA-Ac cells cerevisiae chains charge ladder Chem chromatin coli correlation cross-beta crystal structure deubiquitination dinucleotide disease DNA sequence domain electrostatic enzyme eukaryotes expression frequencies function Gcn5 genes Genet genomic HDAC inhibitors high-throughput histone acetylation histone acetyltransferase histone H2B histone H3 homopeptides homorepeat regions homorepeats human inclusion bodies increase interactions linker lysine lysine residues mapped Mavrich mice microarray MNase module molecular molecules mouse models mutant ATXN7 mutations N-terminal Natl NDRs negative charge nucleo nucleosomal DNA nucleosome core particle nucleosome occupancy nucleosome positions observed pathway PCAF peptide poly-A polyglutamine polyglutamine-expanded ATXN7 polypeptide potential predicting nucleosome prion Proc promoters protein aggregation Purkinje cells result role SAGA complex SCA7 sequence reads SOD1 specific stability STAGA steric studies substrate subunit superoxide dismutase surface surfactant tion transcription factors transgenic vitro vivo yeast