Advances in Protein Chemistry and Structural Biology, Volume 80
Academic Press, Dec 16, 2010 - Science - 296 pages
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
What people are saying - Write a review
Targeted metabolomics and mass spectrometry
Mechanisms of protein circular dichroism insights from computational modeling
Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by highthroughput homology modeling
Positive and negative modulation of nicotinic receptors
Other editions - View all
Advances in Protein Chemistry and Structural Biology, Volume 81
Alexander McPherson,David S. Eisenberg,Rossen Donev
No preview available - 2010