Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers
Gabriella Castoria, Antimo Migliaccio
Springer Science & Business Media, Dec 15, 2011 - Medical - 270 pages
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
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Acad Sci U S A action of steroid androgen receptor assays association binding Biochem Biol Chem biological breast cancer cells c-Src Cell Biol cell lines cell proliferation cellular chromatin Clin clinical complex coregulators CRPC domain e-mail effects EGFR epidermal growth factor epithelial cells ER-a estradiol estrogen receptor alpha function gene expression genomic GPER growth factor receptor HER2 histone human breast cancer IGF-IR increased induces inhibition inhibitors insulin-like growth factor interaction invasion involved levels ligand lipid LNCaP cells MAPK mechanisms mediated metastasis metastatic methylation mice Migliaccio Mol Cell Mol Endocrinol molecular mutations Natl Acad Sci non-genomic action nuclear receptor Oncogene Oncol patients phosphorylation PI3K plasma membrane Proc Natl Acad progesterone receptor promoter prostate cancer prostate cancer cells protein kinase protein-coupled receptor regulation response role sex steroids signaling pathways steroid hormones steroid receptors stimulation stromal studies tamoxifen therapy tissue transcription factors transcriptional activity translocation tyrosine kinase xenoestrogens