Advances in Brain Resuscitation

Front Cover
H. Takeshita, B.K. Siesjö, J.D. Miller
Springer Japan, Jun 3, 1991 - Medical - 329 pages
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Brain resuscitation is the therapeutic intervention for critically ill patients with severe brain damage, particularly the types caused by ischemia and hypoxia. The The objective of the International Symposium on Brain Resuscitation held in Ube, Yamaguchi Japan October 31 to November 2 1988, and sponsored by Yamaguchi University and the Japanese Ministry of Education, was to review our recent progress in brain resuscitation and to discuss controversies both basic and clinical. To my knowledge, this symposium was the first held in Japan. Our understanding of neuronal dysfunction due to ischemic/hypoxic insults at organ, cellular, and molecular levels has advanced significantly in the last two decades. We had therefore intended that this international symposium should broadly cover the topics which are of interest to both basic researchers and clinicians. Three hundred and twenty-five attendants, including twenty scientists from eight different countries, actively participated in discussion and exchange of new ideas and thoughts concerning brain resuscitation. This book comprises the re ports presented during the symposium which consisted of two main parts: basic and clinical. Although one single meeting can never be expected to solve any problems, meetings often highlight areas of ignorance and problems which are ripe for solving. It has been hard to review all the papers because of the multi plicity of the discussed topics, but the overview on brain resuscitation by Profes sor Bo K. Siesjo and the summary by Professor J.

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Contents

Neurobehavioral Changes Following Cerebral Ischemia
9
Glutamate Neurotoxicity and Ischemic Neuronal Damage
21
Are GlutamateAspartate Antagonists Protective in Cerebral
45
Is It Important in Ischemic
59
Metabolic Derangement and Cell Damage in Cerebral Ischemia with
77
of Gerbils
99
Protective Effect of Microinjury in Brain Ischemic Damage
115
Behavioral and Memory Impairment Following Cerebral Ischemia
123
Cerebral Protection With Barbiturates Nizofenone and Steroids
183
Anesthetic Protection in Brain Ischemia
195
The Role of Calcium Entry Blockers in Brain Ischemia
211
Management of Brain Edema in Head Injury
221
Monitoring and Prediction
233
Multimodal Neuromonitoring of Patients With Severe Brain Damage
247
ShortLatency Somatosensory Evoked Potentials SSEPs
267
Monitoring Evoked Potentials and Cerebral Circulatory Index
275

The Effects of Sodium Bicarbonate on Cerebrospinal Fluid Acid
151
Effects of Dichloroacetate on Survival Rate Brain ATP Lactate
165
Effects of HeparinUrokinase Diazepam or Nimodipine on Brain
173
Selection of Candidates
289
a Clinical Perspective
315
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