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The Rational Approach
SUGARMODIFIED OLIGONUCLEOTIDES AS POTENTIAL
Inhibitory Effect of aDNARNA Duplex
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2-5A synthetase 3'-azido-3'-deoxythymidine 5'-nucleotidase Acad Agents Chemother Alabama at Birmingham anti-HIV anti-HIV-1 activity Antimicrob antiviral activity antiviral agents Ap4A assay Balzarini BFU-E binding Biochem bone marrow bone marrow cells Broder C-IdUrd Cancer carbocyclic analog carbocyclic nucleoside analogs carbovir cellular CFU-GM Chem chemotherapy Chemotherapy of AIDS Clercq clinical clonogenic assays complementary compounds crystals cytopathic effects ddAdo degradation density double-stranded drug duplex enzyme HIV-infected human bone marrow human immunodeficiency virus Imbach infected inhibition inhibitors interaction intercalation interferon mismatched dsRNA therapy Mitsuya molecular molecules Morvan mRNA Natl nucleic acid oligodeoxyribonucleotide oligonucleotides patients PBM cells Pharmacology phosphorylation polyoxometalates polyoxotungstates potential Proc protein Prusoff purine pyrimidine Renal replication reverse transcriptase ribavirin RNase H Schinazi Sommadossi Strekowski structure studies substrate Suhadolnik Synergistic synthesis Table target toxicity tumor unfused uninfected uridine uridine phosphorylase viral virus in vitro virus type viruses vitro vivo