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Pharmacokinetics of glucuronidation in the rat in vivo and
Multiple Forms of UDP
27 other sections not shown
1-naphthol 2-acetylaminofluorene affinity amidation antibody assay bile acids bile alcohol biliary excretion bilirubin UDP-glucuronyltransferase activity bilirubin-IXa binding Biochem Biol biotransformation Bock Burchell Cancer Res catalysed Chem chemical chenodeoxycholic acid chromatography Clin colon compounds concentration conjugation conjugation reactions cytochrome P-450 determined dose drug metabolizing effect endogenous endoplasmic reticulum enzyme enzyme activity ester extrahepatic Figure formation fraction glucuronic acid glucuronic acid conjugation glucuronidation glucuronide conjugation glucuronyltransferase Golgi guinea-pig Gunn rat Heirwegh hepatic hepatocyte hepatocyte nodules human liver increased incubation induced inhibition isoenzymes isolated kinetic lignans lipid membranes metabolites microsomal UDP-glucuronyltransferase microsomes mmol/l molecular weight monoglucuronide morphine mucosal observed oestrone p-nitrophenol paracetamol patients perfused pharmacokinetics Pharmacol phenobarbital phenol phospholipid plasma preparations pretreatment protein purified rat liver microsomes serum steroid studies subcellular substrate subunit sulphate Table taurine testosterone tion tissue tumour UDP-glucuronic acid UDP-glucuronyltransferase UDPGA UDPGT unconjugated uridine urine vitro vivo xenobiotics