Advances in the Prevention and Treatment of Inflammation-Associated Preterm Birth

Front Cover
Jeffrey A. Keelan, John P. Newnham
Frontiers Media SA, Aug 16, 2016 - Neurosciences. Biological psychiatry. Neuropsychiatry - 101 pages

 After decades of intensive research and over 10,000 publications, preterm birth remains a major global obstetric healthcare problem. Each year, early birth is responsible for the deaths of more than one million infants worldwide and is a major cause of life-long disability. Preterm birth places an enormous financial burden on our healthcare systems, resulting in long-term adverse health outcomes and lost productivity for many people. 


Preterm birth is a syndrome, associated with several different aetiologies; hence, potential treatment strategies need to be matched to pathophysiology in order to be effective. There is now unequivocal evidence that inflammation is causally involved in a majority of spontaneous preterm deliveries. However, the triggers of inflammation, and the strategies by which it can be safely and effectively prevented and treated, remain the subject of ongoing investigation and debate. While intraamniotic infection is an important cause of inflammation-associated preterm birth, particularly in very preterm deliveries, ‘sterile’ inflammation is actually a more common finding associated with preterm birth. 

It is likely that the nature, localisation, timing and extent of the inflammatory insult all determine the obstetric outcome and degree of risk to the fetus. These factors will also influence the success of approaches that might be employed to achieve better pregnancy outcomes. Despite our increased understanding of the causes and significance of intrauterine inflammation, we have yet to translate this knowledge into effective therapeutic strategies for preventing prematurity and mitigating its consequences for the neonate. 

In this Research Topic we review recent progress in treating and preventing inflammation-associated preterm birth, approaching the topic from both the causal and therapeutic perspectives. With global attention increasingly focused on the need to translate knowledge discovery into clinical translation, we hope this EBook will provide a stimulating and timely discussion that will focus research and lead to improved healthcare outcomes for women and children.
 

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Contents

Advances in the Prevention and Treatment of InflammationAssociated Preterm Birth
5
Strategies to prevent preterm birth
7
Preterm birth intrauterine infection and fetal inflammation
19
an overview of the uterine microbiome
30
The maternal serological response to intrauterine Ureaplasma sp infection and prediction of risk of preterm birth
42
Oxidative stress damage as a detrimental factor in preterm birth pathology
49
Drugs to block cytokine signaling for the prevention and treatment of inflammationinduced preterm birth
63
Is there a role for probiotics in the prevention of preterm birth?
71
Advances in the Prevention of InfectionRelated Preterm Birth
79
A New Potent and PlacentaPermeable Macrolide Antibiotic Solithromycin for the Prevention and Treatment of Bacterial Infections in Pregnancy
91
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