Advancing Prion Science: Guidance for the National Prion Research Program

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National Academies Press, Mar 18, 2004 - Medical - 259 pages
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In Advancing Prion Science, the Institute of Medicine s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
 

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Contents

Executive Summary
1
Summary
5
1 Introduction
33
An Overview
39
3 Basic Biomedical Research on Transmissible Spongiform Encephalopathies
60
4 Diagnostics for Transmissible Spongiform Encephalopathies
72
5 Testing Blood for Evidence of the Agents of Transmissible Spongiform Encephalopathies
108
6 Surveillance for Transmissible Spongiform Encephalopathies in the United States
125
8 Infrastructure for Research on Transmissible Spongiform Encephalopathies
214
9 Risk of Transmissible Spongiform Encephalopathies to the US Military
223
APPENDIXES
231
A Agendas of Open Sessions of Committee Meetings
233
B Biographical Sketches
243
Glossary
250
PLATES
259
Copyright

7 Assessment of Strategies to Prevent and Treat Transmissible Spongiform Encephalopathies
160

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