Adverse Cutaneous Drug Eruptions

Front Cover
Lars E. French
Karger Medical and Scientific Publishers, 2012 - Medical - 240 pages
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An indispensable tool for understanding, diagnosing and managing this common clinical problem The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1-5% for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists.
 

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Contents

Epidemiology of Cutaneous Adverse Drug Reactions
1
Genetics and the Potential for Predictive Tests in Adverse Drug Reactions
18
Etiology and Pathogenesis of Adverse Drug Reactions
32
Diagnostic Approach to Drug Allergy
47
Histopathological Patterns Indicative of Distinct Adverse Drug Reactions
61
Uncomplicated DrugInduced Disseminated Exanthemas
79
DrugInduced Angioedema
98
The Dark Side of Activation of Intraepidermal CD8+ T Cells Uniquely Specialized to Mediate Protective Immunity
106
StevensJohnson Syndrome and Toxic Epidermal Necrolysis
149
Phototoxic and Photoallergic Cutaneous Drug Reactions
167
Immediate and Delayed Cutaneous Reactions to Radiocontrast Media
180
Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs
191
Cutaneous Drug Eruptions Associated with the Use of Biologics and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases
203
Desensitization for Hypersensitivity Reactions to Medications
217
Author Index
234
Subject Index
235

Recent Advances in the Diagnosis Pathogenesis and Management
122
Acute Generalized Exanthematous Pustulosis
139
Cover
241
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