Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality
National Academies Press, Jan 15, 1993 - Medical - 447 pages
Childhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization.
This volume provides the most thorough literature review available about links between common childhood vaccines--tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b, and hepatitis B--and specific types of disorders or death.
The authors discuss approaches to evidence and causality and examine the consequences--neurologic and immunologic disorders and death--linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders.
This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents.
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1 Executive Summary
2 Causality and Evidence
3 Neurologic Disorders
4 Immunologic Reactions
5 Diphtheria and Tetanus Toxoids
6 Measles and Mumps Vaccines
7 Polio Vaccines
8 Hepatitis B Vaccines
11 Need for Research and Surveillance
APPENDIX A Executive Summary from Adverse Effects of Pertussis and Rubella Vaccines
APPENDIX B Strategies for Gathering Information
APPENDIX C Glossary
APPENDIX D Committee and Staff Biographies
9 Haemophilus influenzae Type b Vaccines
Other editions - View all
acute adverse event adverse reactions allergic American Journal American Medical Association anaphylaxis antibody antigen arthritis aseptic meningitis biologic plausibility British Medical Journal causal relation cause Centers for Disease committee conjugate vaccine death developed Disease Control doses encephalitis encephalopathy England Journal Epidemiology evidence favors following administration following immunization following vaccination Guillain-Barré syndrome Haemophilus influenzae type hepatitis B vaccine Hib disease Hib vaccines hypersensitivity IDDM immunogenicity immunologic inadequate to accept incidence infants Infectious Disease Journal Institute of Medicine Journal of Diseases Journal of Infectious Journal of Medicine Journal of Pediatrics Lancet live attenuated measles virus mumps vaccine neurologic neuropathy occurred onset orchitis paralytic poliomyelitis patients Pediatric Infectious Disease Pediatrics percent pertussis polio vaccine poliomyelitis poliovirus polysaccharide protein reject a causal reports rubella rubella vaccine seizures serum SIDS SSPE subacute sclerosing panencephalitis surveillance symptoms tetanus toxoid thrombocytopenia transverse myelitis Uncontrolled Observational Studies vaccine letter VAERS viral