Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality

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National Academies Press, Jan 15, 1993 - Medical - 447 pages
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Childhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization.
This volume provides the most thorough literature review available about links between common childhood vaccines--tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b, and hepatitis B--and specific types of disorders or death.
The authors discuss approaches to evidence and causality and examine the consequences--neurologic and immunologic disorders and death--linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders.
This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents.
 

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Contents

1 Executive Summary
1
2 Causality and Evidence
19
3 Neurologic Disorders
34
4 Immunologic Reactions
59
5 Diphtheria and Tetanus Toxoids
67
6 Measles and Mumps Vaccines
118
7 Polio Vaccines
187
8 Hepatitis B Vaccines
211
10 Death
274
11 Need for Research and Surveillance
305
APPENDIX A Executive Summary from Adverse Effects of Pertussis and Rubella Vaccines
309
APPENDIX B Strategies for Gathering Information
318
APPENDIX C Glossary
335
APPENDIX D Committee and Staff Biographies
342
Bibliography
348
Index
451

9 Haemophilus influenzae Type b Vaccines
236

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