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NOMENCLATURE AND DEFINITIONS
Birth prevalence of congenital abnormalities in Hungary
MULTIFACTORIAL THRESHOLD MODEL
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1000 total births 10emale 1able 1otal 9 ICCAs Aale aetiology affected anencephaly Baranya county BB-population bilateral birth order birth prevalence birth weight boys Budapest Carter cent CHPS chromosomal CL(P cleft common concordance congenital abnormalities Czeizel diagnosis distribution dominance variance encephalocele environmental factors epidemiological ES-sample evaluated familial cluster family study fathers female first-degree relatives frequency GAMT programme genes gestation girls h2 values HCMR higher hormonal Hungarian Hungary ICCAs ICCAs investigated increased index patients infant inheritance intrauterine isolated VSD joint laxity live births male manifestation maternal age mothers multiple CAs including MZ twins newborns nosological observed occurrence offspring orthopaedic paediatric parents polygenic liability polygenic system population pregnancy prevalence of ASB recurrence risk relativ7 sample sex ratio sibs significant spina bifida cystica STEV stillbirth syndromes Szolnok Table talipes equinovarus teratogenic third-degree relatives threshold triggering twin pairs types