Age and susceptibility to toxic substances
Investigates the relationship between age and environmentally induced diseases, which must be taken into consideration in establishing acceptable exposure standards for high-risk groups in society. Assesses the effect of age on gastrointestinal and dermal absorption of toxic substances and drugs, and age differences in plasma protein binding and xenobiotic metabolism. Contains several chapters on organ-specific toxicity differences according to age. Also discusses genotoxicity and environmentally induced cancer. A final chapter synthesizes the information and addresses the relevance of this knowledge to biological basis of safety considerations.
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B Dermal Absorption
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0harles River 0prague 6ral 6ral 6ral absorption acetaminophen acid acute toxicity Adult Adult adult levels adult rats age groups age-dependent age-related differences agents assessed bilirubin binding Biochem Biol birth blood brain carcinogen cells Clin conjugation Dawley days of age decrease developmental DMBA dose drug effect of age elderly enzyme enzyme activity ethanol etidocaine exposure factors fetal function gentamicin glucuronidation greater guinea pigs hepatic human immature increased induced infants intestinal kidney Klaassen liver lung male mammary metabolism methemoglobinemia mg/kg mice microsomal months of age mouse neonatal neonatal rat nephrotoxicity neurotoxic newborn rat nondisjunction occur old rats ouabain oxidation oxygen paraquat Pediatrics pentobarbital Pharm Pharmacol Physiol plasma postnatal Proc protein pulmonary rabbits radiation Rat Rat Rat Ratc REFERENCES renal reported sensitivity skin species studies substrates superoxide dismutase T-2 toxin Ther tissue Toxicol tumors weanling weeks Wistar Wistar rats young adult young rats zoxazolamine