Aging, Volume 1
Edward J. Masoro
American Physiological Society, 1995 - Aging - 681 pages
The aims of this new section of the Handbook of Physiology are two. One is to present a source of basic knowledge about aging including research approaches for use by physiologists as well as other biologists not directly involved in aging research. The other is to provide comprehensive information for gerontologists on the physiological characteristics of aging in mammals, particularly humans. The principles of biological gerontology are presented in Part I, which includes discussions of approaches to the measurement of the rate of aging of populations, the difficulty of assessing aging of the individual, theoretical concepts regarding the nature of aging, and conceptual issues concerning the relationship between aging and disease. Methodological issues unique to aging research are presented in Part II. The focus is on study design and analysis and on cell culture models, animal models and human subject use. Part III provides a detailed description of the cellular and noncellular aspects of aging. This part also discusses the metabolic characteristics of aging. In Part IV, twelve chapters provide comprehensive coverage of the influence of age on the physiology of the nervous systems and the organism. Interventions of aging processes, proposed and established, are the subject of Part V.
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Design and Analysis of Aging Studies
Cell Culture as a Model
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absorption acid activity adult age-associated age-related changes aged rats Ageing Dev aging processes altered Alzheimer's disease animals arterial basal Biochem Biol biological body bone loss brain c-fos calcium cardiac cartilage cellular chronic Clin collagen cross-links culture decline decreases with age degradation diabetes diabetes mellitus dietary restriction diploid edited effect of age elastin elderly Endocrinol enzymes exercise Female fibroblasts function gene expression genetic Gerontol glucocorticoid glucose glycation heart human hypertension impaired increase insulin insulin resistance intestinal lens levels liver lung Maillard reaction Male Fischer 344 measured Mech mechanisms membrane Metab metabolic rate metabolism mice months mouse mRNA muscle neurons normal obesity occur older individuals osteoporosis oxidation Physiol physiological plasma population protein synthesis proteoglycans receptor reduced renal response rodents role senescent senescent cells skin span species Sprague-Dawley subjects tion tissue transcription turnover ventricular vitro vivo Wistar young