Aging Research in Yeast
Michael Breitenbach, S. Michal Jazwinski, Peter Laun
Springer Science & Business Media, Nov 19, 2011 - Science - 368 pages
This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
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3 The Role of Mitochondria in the Aging Processes of Yeast
4 The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging
5 Chronological Aging in Saccharomyces cerevisiae
6 Aging and the Survival of Quiescent and Nonquiescent Cells in Yeast StationaryPhase Cultures
7 Maximising the Yeast Chronological Lifespan
8 Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae
9 DNA Damage and DNA Replication Stress in Yeast Models of Aging
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accumulation actin activity Aging Cell amino acid apoptosis apoptosis in yeast apoptotic asymmetry autophagy Biol Chem Breitenbach budding yeast Caenorhabditis elegans caloric restriction calorie cell cycle cell death cellular chronological aging chronological life span chronological longevity complex cultures cytoskeleton daughter cells deletion DNA damage DNA replication elegans encoding enzymes ERCs eukaryotes extends Fabrizio gene expression genome glucose glutaredoxin glutathione growth Guarente identified increased induced involved Kaeberlein Kennedy BK kinase Laun lifespan Longo VD Madeo F mammalian mechanisms membrane metabolism metacaspase Microbiol mitophagy Mol Biol Cell molecular mother cells mRNA mutants non-quiescent cells nutrients oxidative damage oxidative stress phenotype pombe protein rDNA reactive oxygen species redox regulation replicative aging replicative life span retrograde response ribosomal role Rtg2 Saccharomyces cerevisiae Sch9 senescence Sir2 span extension stationary phase stem cells strains stress response studies superoxide survival thioredoxin TORC1 transcription factor wild type Yap1p yeast cells yeast replicative