Aging Research in Yeast

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Michael Breitenbach, S. Michal Jazwinski, Peter Laun
Springer Science & Business Media, Nov 19, 2011 - Science - 368 pages
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This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
 

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Contents

1 Introduction
1
2 Oxidative Stresses and Ageing
13
3 The Role of Mitochondria in the Aging Processes of Yeast
55
4 The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging
79
5 Chronological Aging in Saccharomyces cerevisiae
101
6 Aging and the Survival of Quiescent and Nonquiescent Cells in Yeast StationaryPhase Cultures
123
7 Maximising the Yeast Chronological Lifespan
145
8 Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae
161
10 Yeast Aging and Apoptosis
207
Impact on the Aging Process
233
12 GenomeWide Analysis of Yeast Aging
251
New Connections and New Opportunities
291
A Modelling Approach
315
15 Cellular Ageing and the Actin Cytoskeleton
331
Index
353
Copyright

9 DNA Damage and DNA Replication Stress in Yeast Models of Aging
187

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