Aging at the Molecular Level

Front Cover
Thomas von Zglinicki
Springer Science & Business Media, Nov 30, 2003 - Medical - 248 pages
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During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation.
Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
 

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Contents

Free radical production an antioxidant defense a primer
1
Oxidative DNA damage and repair implications for aging
11
Oxidative damage to proteins
27
Aging rate mitochondrial free radical production and constitutive sensitivity to lipid peroxidation insights from comparative studies
47
Genomic instability in human premature aging
65
Oxidative damage somatic mutations and cellular aging
79
Mitochondria and aging
91
Biological clocks in the aging cell
107
Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice
131
Nonoxidative modification of DNA and proteins
145
Transcriptional and translation dysregulation during aging
179
Metabolic regulation of gene silencing and life span
193
The proteasome is aging
213
Aging lysosomal degradarion of cellular constituents
233
Index
243
Copyright

Telomeric damage in aging
121

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