Aging at the Molecular Level
Thomas von Zglinicki
Springer Science & Business Media, Nov 30, 2003 - Medical - 248 pages
During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation.
Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
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Free radical production an antioxidant defense a primer
Oxidative DNA damage and repair implications for aging
Oxidative damage to proteins
Aging rate mitochondrial free radical production and constitutive sensitivity to lipid peroxidation insights from comparative studies
Genomic instability in human premature aging
Oxidative damage somatic mutations and cellular aging
Mitochondria and aging
Biological clocks in the aging cell
Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice
Nonoxidative modification of DNA and proteins
Transcriptional and translation dysregulation during aging
Metabolic regulation of gene silencing and life span
The proteasome is aging
Aging lysosomal degradarion of cellular constituents
Telomeric damage in aging
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20S proteasome Acad Sci USA accumulation acid residues age-related amino acid antioxidant apoptosis Biochem Biophys Biogerontology Biol Chem caloric restriction carbonyl carnosine cellular senescence cerevisiae cross-linked culture deacetylase deamidation decrease degradation disease DNA glycosylase DNA repair Drosophila enzymes Exp Gerontol fatty acid fibroblasts Free Radic Biol free radical gene expression Genet genome glutathione glycation histone human fibroblasts increased induced inhibition levels lifespan lipid peroxidation lipofuscin liver longevity lysine lysosomal mammalian Mech Ageing Dev mechanism membrane metabolic methylation mice mitochondrial DNA MLSP modification molecular molecules mouse mtDNA mutations Natl Acad Sci overexpression oxidative damage oxidative stress oxidized proteins pathway peptides phenotype polymerase Proc Natl Acad production proteasome proteasome activity protein oxidation protein synthesis reaction regulation replicative senescence ribosomal role Sir2 Sohal span structure studies subunits superoxide dismutase telomerase telomere telomere shortening theory of aging tissues transcription transgenic vitro vivo Werner syndrome yeast Zglinicki