Aging of Cells in and Outside the Body

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S. Kaul, Renu Wadwha
Springer Science & Business Media, Oct 31, 2003 - Science - 276 pages
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This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.
 

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Contents

Aging Outside the Body Usefulness of the Hayflick System
1
Genetics of Cellular Aging
9
Aging of Fibroblasts
27
Aging of Endothelial Cells
47
In Vitro Senescence of Human Osteoblasts
67
T Cell Immunosenescence
85
Aging of PrematureAging Syndrome Cells
101
The p53 Pathway Cancer and Aging
121
Regulation of Cellular Senescence by the Retinoblastoma Pathway
151
Telomeres and Cellular Aging
171
Molecular Chaperones and Cellular Aging
207
Cellular Senescence Pathways in Mouse and Human
225
Therapeutic Induction of Cellular Senescence Nuclear Matrix in Senescence
239
Use of Hammerhead Ribozymes for Aging and Cancer
257
Index
269
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