Agmatine and imidazolines: their novel receptors and enzymes

Front Cover
New York Academy of Sciences, 2003 - Medical - 449 pages
0 Reviews
The diversity of imidazoline receptor (IR) subtypes as well as a wide tissue distribution of imidazoline-selective binding sites has led to an appreciation that other organ systems besides the brain are also probably influenced by IRs. Furthermore, the discovery and characterization of two endogenous IR ligands (agmatine and harmane) have pointed to the potential therapeutic value of these agents in unexpected areas like brain trauma and psychiatry. Agmatine acts as a neuroprotective agent in brain trauma as well as an agent capable of alleviating chronic pain, drug withdrawal syndromes, and inflammatory responses. This volume serves as a guidepost to these agents' usefulness in other unexpected areas, including diabetes and related metabolic syndromes, drug addiction, and neuropathic pain.

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Regulation of Inducible Nitric Oxide Synthase and Agmatine Synthesis
20
What Role Do They Play in Agmatine Catabolism?
30
At the Crossroads of the Arginine Pathways By Joseph Satriano
34
Distribution in Tissues and Organs
44
StructureActivity Analysis of Guanidine Group in Agmatine for Brain Agmatinase
52
Agmatine Crosses the BloodBrain Barrier By J E PlLETZ P J May G Wang
64
Identification and Pharmacological Characterization of a Specific Agmatine
75
Neuropharmacokinetic and Dynamic Studies of Agmatine Decarboxylated Arginine
82
Endogenous Imidazoline Receptor Ligands Relax Rat Aorta by
222
Where
228
Are Centrally Acting Imidazoline Agents Appropriate Therapy for Renovascular
234
Cardiac Effects of Moxonidine in Spontaneously Hypertensive Obese Rats
244
The Role of I rImidazoline Receptors and a2Adrenergic Receptors in the Modulation
251
Involvement of Forebrain Imidazoline and oAdrenergic Receptors in
262
Norepinephrine Release Is Reduced by IrReceptors in Addition to Adrenoceptors
270
Normalization of UpRegulated Cardiac Imidazoline I rReceptors and Natriuretic
274

Effect of Agmatine on Acute and Mononeuropathic Pain By Feyza ARICIOGLU
106
Spinal and Supraspinal Agmatine Activate Different Receptors to Enhance
116
Is Agmatine an Endogenous Factor Against Stress? By Feyza Aricioglu
127
AgmatineMorphine Interaction on Nociception in Mice
133
Effect of Agmatine on Electrically and Chemically Induced Seizures in Mice
141
Agmatine Inhibits NaloxoneInduced Contractions in MorphineDependent
147
Endogenous BCarbolines as ClonidineDisplacing Substances By E S J Robinson
157
Comparative Effects of Efaroxan and BCarbolines on the Secretory Activity
167
Effect of Harmane on Mononeuropathic Pain in Rats fly Feyza ARICIOGLU
180
Effect of Harmane on the Convulsive Threshold in Epilepsy Models in Mice
190
Harmane Induces Anxiolysis and AntidepressantLike Effects in Rats
196
Complex Interaction of 02Adrenoceptor Binding Sites with Bovine Brain
216
BU98008 a Highly Selective ImidazolineReceptor Ligand By E S J ROBINSON
283
Atypical 3HClonidine Binding Sites in Human Caudate and Platelets
296
Novel Ligands for the Investigation of Imidazoline Receptors and Their Binding
302
The Effects of Chronic Administration of Inhibitors of Flavin and Quinone Amine
309
In Vivo Effects of the I2Alkylating Agent BU99006 on the Immunodensity
323
Restoration of FirstPhase Insulin Secretion by the Imidazoline Compound
332
Effect of Postmortem Delay on Imidazoline ReceptorBinding Proteins in Human
341
Association Between I2 Binding Sites and Monoamine OxidaseB Activity
347
Relationship Between Imidazoline2 Sites and Monoamine Oxidase
353
Investigation of the Affinities of Two New PCarbolines for Rat Brain Imidazoline
361
In Vivo Estimation of Imidazoline Binding Site Turnover By L M Paterson
367
Copyright

Other editions - View all

Bibliographic information