Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Front Cover
Kian Fan Chung
John Wiley & Sons, Apr 30, 2008 - Science - 326 pages
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In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified.

 

Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management.

 

  • Authoritative update on key mechanisms of airway constriction in Asthma and COPD
  • Relates latest research to bronchodilator therapy
  • Multi-contributed text, co-coordinated by two of the leading authorities in the field.
 

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Contents

1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma
1
2 Dynamics of cytoskeletal and contractile protein organization an emerging paradigm for airway smooth muscle contraction
31
3 Airway smooth muscle role in airway constrictor hyperresponsiveness
53
4 Airway smooth muscle phenotypic and functional plasticity
71
5 Airway smooth muscle proliferation insights into mechanisms regulating airway smooth muscle mass
89
6 Airway smooth muscle bidirectional interactions with extracellular matrix
105
7 Airway smooth muscle interaction with mast cells
127
8 Airway smooth muscle synthesis of inflammatory mediators
141
10 Altered properties of airway smooth muscle in asthma
181
11 The airway smooth muscle in chronic obstructive pulmonary disease COPD
201
12 Glucocorticoid actions on airway smooth muscle
235
13 B2Adrenergic receptors effects on airway smooth muscle
255
14 Asthma treatments effects on the airway smooth muscle
277
Index
303
Color Plates
313
Copyright

9 Airway smooth muscle in experimental models
159

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