Airways Smooth Muscle: Modelling the Asthmatic Response in Vivo

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David Raeburn, Mark A. Giembycz
Springer Science & Business Media, May 1, 1996 - Medical - 300 pages
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Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.
 

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Contents

Measurement of Airways Smooth Muscle Responsiveness in Animals
1
Methods of Drug Administration to the Lung in Animals
27
PAF and AntigenInduced Bronchial Hyperreactivity in Guinea Pigs
51
AntigenInduced Bronchial Hyperreactivity in Rats
75
OzoneInduced Bronchial Hyperreactivity
95
VirusInduced Bronchial Hyperreactivity
121
The Rabbit Model of Asthma and the Late Asthmatic Response
147
The Sheep as a Model of the Late Asthmatic Response
171
Primate Models of Asthma
191
The Sensitized Pig Model of Asthma
225
Transgenic Animals and the Modelling of Asthma
241
Index
275
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About the author (1996)

Sophocles (496 BCa406 BC) wrote more than a hundred plays for the Athenian theater, including "Antigone, Oedipus the King," and "Oedipus at Colonus," His life spanned the rise and decline of the Athenian Empire. David Raeburn is a lecturer in classics at Oxford and the translator of the Penguin Classics edition of Ovidas "Metamorphoses," Pat Easterling is a former Regius Professor of Greek at Cambridge.

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