Airways smooth muscle: structure, innervation, and neurotransmission
David Raeburn, Mark A. Giembycz
Birkhäuser Verlag, 1994 - Medical - 328 pages
Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.
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List of Contributors VI
Excitatory Nonadrenergic Noncholinergic Innervation
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acetylcholine action potentials activity adrenergic adrenoceptor afferent agonists airways ganglia airways ganglion neurones airways neurones airways smooth muscle antagonists Appl Physiol asthma atropine axon Barnes PJ Belvisi MG bradykinin bronchi bronchial smooth muscle bronchoconstriction bronchodilator bronchomotor C-fibre capsaicin capsaicin-sensitive cholinergic cholinergic nerves cholinergic neurotransmission contraction cough dogs endogenous epithelium ferret function guinea guinea-pig guinea-pig airways guinea-pig trachea histamine human airways i-NANC response induced inflammatory inhaled inhibition inhibitory effect innervation Lundberg JM lung M2 cholinoceptor mechanisms mediated membrane modulation muscarinic cholinoceptor muscarinic receptors muscle cells Nadel NANC nerve fibres nerve stimulation nerve terminals neural neurokinin neuromodulation neuropeptide neurotransmission nitric oxide nitric oxide synthase nonadrenergic noncholinergic parasympathetic ganglia pathways Pharmacol 1991 preganglionic prejunctional pulmonary reflex release respiratory tract Rev Respir role sensory nerves smooth muscle tone studies substance suggesting tachykinins tissue trachea tracheal smooth muscle tracheobronchial vagal vagus nerve vasoactive intestinal peptide vitro vivo