Alcohol and Neurobiology: Receptors, Membranes and Channels
Ronald Ross Watson
CRC Press, Jun 24, 1992 - Science - 336 pages
Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol abuse, particularly its neurological consequences. Two out of three high school students report that they used alcohol during the previous month. This continuing source of potential abusers, plus 10 million alcohol-abusing adults, along with the several million abusers of other drugs, costs the people of the U.S. more than $200 billion in lost wages, health care, theft, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its actions. These include modifications of hormonal regulation and production with major functional consequences. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.
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Ethanol and AgonistInduced Desensitization of
Differential Sensitivity of Nigrotectal GABA Neurons
Insights into the Molecular Mechanism of Action
Other editions - View all
Alcohol and Neurobiology: Brain Development and Hormone Regulation
Ronald R. Watson
Limited preview - 1992
Acad acid Acta action of ethanol activity acute alcohol alter anesthetics animals anticonvulsant anxiolytic anxiolytic action behavior benzodiazepine bicuculline bilayer binding sites Biochem biological membranes Biophys brain regions Brain Res calcium channels changes channel antagonists cholesterol chronic ethanol consumption chronic ethanol treatment crayfish cytofacial leaflet decrease desensitization dopamine doses drugs effects of alcohol effects of chronic effects of ethanol enhancement erythrocyte Ethanol inhibits ethanol withdrawal ethanol-fed ethanol-induced exofacial and cytofacial exofacial leaflet exposure fluidity flumazenil function GABA GABAA receptor GABAergic hippocampal increase inhibitory interaction inverse agonist LS and SS mechanisms membrane lipids muscimol Natl Neurochem neurons Neurosci neurotransmitter nigra NMDA receptor partition coefficients PC12 cells pentobarbital Pharmacol phase phospholipid Physiol plasma postsynaptic presynaptic Proc protein rat brain reduced response seizures sensitivity specific SS mice striatal striatonigral studies substantia nigra subtypes subunit synaptic synaptosomes Ther tolerance vitro vivo voltage-dependent calcium channels voltage-gated