Alcohol and Neurobiology: Receptors, Membranes and Channels

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Ronald Ross Watson
CRC Press, Jun 24, 1992 - Science - 336 pages
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Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol abuse, particularly its neurological consequences. Two out of three high school students report that they used alcohol during the previous month. This continuing source of potential abusers, plus 10 million alcohol-abusing adults, along with the several million abusers of other drugs, costs the people of the U.S. more than $200 billion in lost wages, health care, theft, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its actions. These include modifications of hormonal regulation and production with major functional consequences. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.
 

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Contents

Chapter
1
Chapter
15
Ethanol and AgonistInduced Desensitization of
23
Chapter 4
37
Differential Sensitivity of Nigrotectal GABA Neurons
51
Chapter 7
91
Chapter 8
109
Insights into the Molecular Mechanism of Action
127
Chapter 10
141
Chapter 11
161
Adaptation of Neuronal Cell Membranes to Chronic
185
Chapter 13
205
Effects of Ethanol on Membrane Lipids
239
Chapter 16
269
Index
303
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About the author (1992)

Ronald Ross Watson, Ph.D., is an internationally recognized nutritionist and immunologist who has studied the importance of nutrients on anti-cancer immune defense for twenty years. He has edited 52 biomedical books and directs four NIH funded biomedical grants.

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