Alcohol Metabolism, Alcohol Intolerance, and Alcoholism: Biochemical and Pharmacogenetic Approaches
Alcohol abuse, alcohol intolerance, alcohol dependence and other alcohol-related disabilities are some of the most challenging public health problems facing our modern-day society. The purpose of this comprehensive monograph is to review the available knowledge concerning the pharmacogenetic basis of alcohol sensitivity and its physiolgical implications and to synthesize the bulk of existing knowledge regarding metabolic features and biomedical disturbances related to alcoholism. The chapters cover a broad array of disciplines including an overview of historical and epidemiological aspects, biochemistry and molecular genetics of enzymes involved in alcohol metabolism, biochemical and neuropsychopharmacological effects of alcohol. Major emphasis is placed on the role of genetic factors in alcoholism. The experimental details are summarized and a comprehensive bibliography is included.
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Biochemical Aspects of Alcoholism
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Alcohol Metabolism, Alcohol Intolerance, and Alcoholism: Biochemical and ...
Dharam P. Agarwal,H. Werner Goedde
No preview available - 1990
abnormal acetaldehyde ADH2 alcohol abuse alcohol consumption alcohol dehydrogenase alcohol drinking alcohol intolerance alcohol metabolism alcohol sensitivity alcohol-related alcoholic liver disease aldehyde dehydrogenase aldehyde dehydrogenase isozymes ALDH activity ALDH isozymes ALDHI allele American Indians amino acid antibodies autopsy livers band biochemical biological blood acetaldehyde levels Bosron brain buffer catecholamines Caucasians cDNA cells Chinese chronic alcohol cirrhosis cirrhotic Clin clones cytosolic detected differences disulfiram effects of alcohol effects of ethanol electrophoretic enzyme activity erythrocyte erythrocyte ALDH ethanol metabolism ethnic factors fractions gene genotypes Goedde HW groups hair root Harada healthy controls hepatic human liver increased isoelectric focusing isozyme deficiency Japanese Lieber Lindros liver ALDH liver damage liver extracts Meier-Tackmann membranes microsomal mitochondrial Mizoi molecular nonalcoholic normal Northern blot observed oxidation patients Pharmacol phenotype Pietruszko plasma propionaldehyde protein reported role Salaspuro samples sequence serum showed significantly studies subcellular substrate subunits Tabakoff tissue twin variation