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Allergen Immunotherapy in Historical Perspective
Genesis of Allergen Immunotherapy
The Early Developmental Years
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Adkinson NF aeroallergen airborne allergen immunotherapy allergen-specific allergenic extracts allergic disease allergic rhinitis Allergy and Immunology Allergy Clin Immunol anaphylactic anaphylaxis Ann Allergy antigen assay asthma atopic AU/ml basophils bioequivalent bronchial cell challenge Clin Allergy Clin Immunol 1989 clinical concentration controlled dander decrease desensitization diagnosis dosage double-blind effects efficacy epinephrine evaluation fungi grass pollen hay fever histamine hornet house dust mite Hymenoptera hyposensitization IgE antibody immunization immunologic Immunology immunotherapy increase inhalant injection insect sting allergy Lichtenstein LM major allergen Medical melittin methacholine mite allergens mold nasal phospholipase placebo pollen extracts proteins puncture test ragweed ragweed extract ragweed pollen RAST reactivity reference extracts relative potency reported respiratory response season sensitivity serum skin test specific spores standardized extracts sting storage mites symptoms systemic reactions Table therapy tion treated treatment urticaria vaccines venom immunotherapy vespid Vial vitro wheal XX XX XX Yunginger JW