Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn
Andrew Hadley, Peter Soothill
Cambridge University Press, 2002 - Medical - 282 pages
Collectively known as the alloimmune cytopenias, this group of disorders arise from maternal immunisation to fetal blood cells. The effective prevention, diagnosis and management of these disorders involves haematologists, obstetricians, paediatricians, immunologists, laboratory technicians, midwives and research scientists. This comprehensive but accessible account is extensively cross-referenced to emphasise the links between pathogenesis and clinical sequelae, between epidemiology and the rationale for screening programmes, and between diagnosis and therapeutic intervention. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology.
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1 Pathophysiology of the alloimmune cytopenias
2 Blood group antibodies in haemolytic disease of the fetus and newborn
3 Basis and practice of screening for haemolytic disease of the fetus and newborn
4 Epidemiology and screening for alloimmune thrombocytopenia
5 Principles of antibodymediated immune suppression and the prevention of maternal RhD alloimmunization
6 The clinical application of antiD prophylaxis
7 Fetal genotyping
8 Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn
10 Antenatal therapy for haemolytic disease of the fetus and newborn
11 Neonatal therapy for haemolytic disease of the newborn
12 The diagnosis of alloimmune thrombocytopenia
13 The immunological diagnosis of alloimmune neutropenia
14 Fetal and neonatal treatment of alloimmune thrombocytopenia
Other editions - View all
Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia ...
Andrew Hadley,Peter Soothill
No preview available - 2005
allele alloantibodies alloantigen alloimmune neutropenia American Journal amino acid anaemia antenatal anti anti-D immunoglobulin anti-HPA-1a antigen assay associated bilirubin blood group blood transfusion British Journal ofHaematology cause HDFN clinical cytopenia D-positive red cells delivery detection diagnosis direct antiglobulin test donors dose effective erythropoiesis exchange transfusion Fc receptor fetal anaemia fetal blood sampling fetal platelet count fetal red cells fetomaternal haemorrhage fetus fetuses genotyping glycoprotein granulocyte haematocrit haemoglobin haemolysis haemolytic disease human hydrops IgG1 Immunology indirect antiglobulin test infants intracranial haemorrhage intrauterine transfusion intravenous isoimmunization IVIG Journal of Obstetrics laboratory levels method molecular monoclonal anti-D monocytes neutropenia neutrophils newborn Obstetrics and Gynecology ofthe patients phenotype plasma plasmapheresis platelet antigens platelet transfusions polymorphism predict pregnancy prophylaxis protein red cell antibodies red cells RHD gene rhesus risk Section sensitized serological serum specificity studies therapy tion titre Transfusion Medicine treatment umbilical Vox Sanguinis weeks