Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and NewbornAndrew Hadley, Peter Soothill Collectively known as the alloimmune cytopenias, hemolytic disease of the fetus and newborn, alloimmune thrombocytopenia and alloimmune neutropenia are all consequences of maternal immunisation to fetal blood cells. The effective prevention, diagnosis and management of these disorders has become a team effort involving haematologists, obstetricians, paediatricians, immunologists, laboratory technicians, midwives and research scientists. This book has been written by experts in their respective fields to bring together the issues of pathogenesis, epidemiology, prevention, diagnosis and clinical management. This comprehensive but accessible account is extensively cross-referenced to emphasise the links between pathogenesis and clinical sequelae, between epidemiology and the rationale for screening programmes, and between diagnosis and therapeutic intervention. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology. |
Contents
1 Pathophysiology of the alloimmune cytopenias | 1 |
2 Blood group antibodies in haemolytic disease of the fetus and newborn | 21 |
3 Basis and practice of screening for haemolytic disease of the fetus and newborn | 41 |
4 Epidemiology and screening for alloimmune thrombocytopenia | 61 |
5 Principles of antibodymediated immune suppression and the prevention of maternal RhD alloimmunization | 73 |
6 The clinical application of antiD prophylaxis | 97 |
7 Fetal genotyping | 121 |
8 Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn | 141 |
clinical aspects | 153 |
10 Antenatal therapy for haemolytic disease of the fetus and newborn | 173 |
11 Neonatal therapy for haemolytic disease of the newborn | 203 |
12 The diagnosis of alloimmune thrombocytopenia | 219 |
13 The immunological diagnosis of alloimmune neutropenia | 235 |
14 Fetal and neonatal treatment of alloimmune thrombocytopenia | 253 |
| 279 | |
Other editions - View all
Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia ... Andrew Hadley,Peter Soothill No preview available - 2005 |
Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia ... Andrew Hadley,Peter Soothill No preview available - 2002 |
Common terms and phrases
allele alloantibodies alloantigen alloimmune neutropenia American Journal amino acid anaemia antenatal anti anti-D immunoglobulin anti-HPA-1a antigen assay associated bilirubin blood group blood transfusion British Journal cause HDFN clinical cytopenia D-positive red cells delivery detection diagnosis direct antiglobulin test donors dose effective erythropoiesis exchange transfusion Fcy receptor fetal anaemia fetal blood sampling fetal platelet count fetal red cells fetomaternal haemorrhage fetus fetuses genotyping glycoprotein granulocyte haematocrit Haematology haemoglobin haemolysis haemolytic disease human hydrops IgG1 Immunology indirect antiglobulin test infants intracranial haemorrhage intrauterine transfusion intravenous isoimmunization IVIG Journal of Haematology Journal of Obstetrics laboratory levels maternal molecular monoclonal anti-D monocytes neonatal alloimmune thrombocytopenia neutropenia neutrophils newborn Obstetrics and Gynecology patients phenotype plasma plasmapheresis platelet antigens platelet transfusions polymorphism predict pregnancy prophylaxis protein red cell antibodies red cells rhesus risk Section serological serum specificity studies therapy tion titre Transfusion Medicine treatment Vox Sanguinis weeks