Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

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Andrew Hadley, Peter Soothill
Cambridge University Press, 2002 - Medical - 282 pages
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Collectively known as the alloimmune cytopenias, this group of disorders arise from maternal immunisation to fetal blood cells. The effective prevention, diagnosis and management of these disorders involves haematologists, obstetricians, paediatricians, immunologists, laboratory technicians, midwives and research scientists. This comprehensive but accessible account is extensively cross-referenced to emphasise the links between pathogenesis and clinical sequelae, between epidemiology and the rationale for screening programmes, and between diagnosis and therapeutic intervention. This is an authoritative overview suitable for trainees in obstetrics, materno-fetal medicine, transfusion medicine and clinical immunology.
 

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Contents

1 Pathophysiology of the alloimmune cytopenias
1
2 Blood group antibodies in haemolytic disease of the fetus and newborn
21
3 Basis and practice of screening for haemolytic disease of the fetus and newborn
41
4 Epidemiology and screening for alloimmune thrombocytopenia
61
5 Principles of antibodymediated immune suppression and the prevention of maternal RhD alloimmunization
73
6 The clinical application of antiD prophylaxis
97
7 Fetal genotyping
121
8 Laboratory assays to determine the severity of haemolytic disease of the fetus and newborn
141
clinical aspects
153
10 Antenatal therapy for haemolytic disease of the fetus and newborn
173
11 Neonatal therapy for haemolytic disease of the newborn
203
12 The diagnosis of alloimmune thrombocytopenia
219
13 The immunological diagnosis of alloimmune neutropenia
235
14 Fetal and neonatal treatment of alloimmune thrombocytopenia
253
Index
279
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About the author (2002)

Dr Andrew Hadley is Division Manager at the International Blood Group Reference Laboratory, and Senior Scientist at the Bristol Institute for Transfusion Sciences, University of Bristol.

Professor Peter Soothill is Professor of Maternal and Fetal Medicine in the Department of Obstetrics and Gynaecology, St Michael's Hospital and University of Bristol.

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