Allostasis, Homeostasis, and the Costs of Physiological Adaptation

Front Cover
Jay Schulkin
Cambridge University Press, Oct 25, 2004 - Medical - 372 pages
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The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
 

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Contents

Principles of Allostasis Optimal Design Predictive Regulation Pathophysiology and Rational Therapeutics
17
Protective and Damaging Effects of the Mediators of Stress and Adaptation Allostasis and Allostatic Load
65
Merging of the Homeostat Theory with the Concept of Allostatic Load
99
Operationalizing Allostatic Load
113
Drug Addiction and Allostasis
150
Adaptive Fear Allostasis and the Pathology of Anxiety and Depression
164
A Chronobiological Perspective on Allostasis and its Application to Shift Work
228
Allostatic Load and Life Cycles Implications for Neuroendocrine Control Mechanisms
302
Viability as Opposed to Stability An Evolutionary Perspective on Physiological Regulation
343
Index
365
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Page 13 - Bauman, DE and WB Currie. 1980. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis.

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