Allostasis, Homeostasis, and the Costs of Physiological AdaptationJay Schulkin The concept of homeostasis is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. This book, the first edited volume to focus on allostasis, orients the reader by addressing basic physiological regulatory systems, and examining bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will appeal to graduate students, medical students, and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology. |
Contents
Principles of Allostasis Optimal Design Predictive Regulation Pathophysiology and Rational Therapeutics | 17 |
Protective and Damaging Effects of the Mediators of Stress and Adaptation Allostasis and Allostatic Load | 65 |
Merging of the Homeostat Theory with the Concept of Allostatic Load | 99 |
Operationalizing Allostatic Load | 113 |
Drug Addiction and Allostasis | 150 |
Adaptive Fear Allostasis and the Pathology of Anxiety and Depression | 164 |
Other editions - View all
Allostasis, Homeostasis, and the Costs of Physiological Adaptation Jay Schulkin Limited preview - 2004 |
Allostasis, Homeostasis, and the Costs of Physiological Adaptation Jay Schulkin No preview available - 2012 |
Common terms and phrases
activity adaptation adrenal allostasis allostatic load allostatic load scores allostatic overload type allostatic regulation amygdala animals anxiety associated behavior biological biomarkers blood pressure body temperature Brain Res calcium cardiovascular catecholamines cells central nucleus challenges changes circadian rhythms Clin concept of allostasis corticosterone corticotropin-releasing hormone cortisol cycle cytokines depression disease disorders drug dysregulation effector effects elevated ELHS emotional environment environmental example fear conditioning feedback function gene glucocorticoids glucocorticosteroids glucose hippocampus history stage homeostasis homeostatic hormone human hypertension hypothalamus immune increased individual insulin Koob lesions levels LHSS McEwen mechanisms mediators metabolic Mrosovsky negative nervous system neural neuroendocrine neurons Neurosci night normal organism pathology pathways Physiol physiological regulation prediction prefrontal cortex processes protein rats receptors regulatory response rheostasis role Rosen Schulkin setpoint shift workers shiftwork signals sleep social Sterling and Eyer stimuli stressor stria terminalis studies suprachiasmatic suprachiasmatic nucleus tion trigger Wingfield
Popular passages
Page 13 - Bauman, DE and WB Currie. 1980. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis.
References to this book
Measuring Stress in Humans: A Practical Guide for the Field Gillian H. Ice,Gary D. James Limited preview - 2006 |