Allosteric Receptor Modulation in Drug Targeting

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Norman G. Bowery
CRC Press, Apr 19, 2016 - Medical - 376 pages
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Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to provide a firm foundation to the subject.
 

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Contents

BASIC PRINCIPLES
1
Chapter 2 Characteristics of Allosterism in Drug Action
19
Mathematical Models of Allosteric ReceptorLigand Interactions
39
IONOTROPIC RECEPTORS
79
Chapter 5 Allosteric Interactions at the NMDA Receptor Channel Complex
93
Chapter 6 5HT3 Receptors
135
Chapter 7 Nicotinic Receptors
155
GPROTEINCOUPLED RECEPTORS
179
Chapter 9 Allosteric Modulators of Group III Metabotropic Glutamate Receptors as Novel Therapeutics
207
Chapter 10 Allosteric Modulation of GABAB Receptors
235
Chapter 11 Allosteric Interactions at GABAB and Related GProteinCoupled Receptors
259
Targeting Allosteric Modulation by the Development and Application of the Radiolabeled Allosteric Agent 3HdimethylW84
287
Physiology Pharmacology and Allosteric Modulation
327
Index
353
Back cover
363
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