alpha2Adrenergic Receptors

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CRC Press, Feb 6, 1997 - Science - 195 pages
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This book undertakes to cover all angles of current research in [actual symbol not reproducible] receptors, each chapter being written by a leader in the field. Starting with an excellent overview of the subject, it provides insights into ligand binding and the effects of site-directed mutagenesis; the transfer of the signal through the G-protein to various effectors and the internal cellular response; receptor trafficking; and the therapeutic implications of the receptors, with the effects of agonists and antagonists.
The scope of this volume makes it an indispensable guide for researchers working on any feature of [actual symbol not reproducible] receptors. It will also prove valuable to anyone with an interest in the structure and function of G-protein coupled receptors and the mechanisms by which they direct the response of the cell to multiple types of external stimuli.
 

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Contents

Structure and Mechanism
19
Delineating Ligandspecific Structural Changes in Adrenergic Receptors
31
Characterization of Stereoselective Interactions of Catecholamines with
43
Regulating Signal Transfer from Receptor to Gprotein
53
Caveolin an Integral Membrane Protein Component of Caveolae Membranes
63
Molecular Determinants of AgonistIndependent Activity in Adrenergic Receptors
77
Adrenergic Receptor Activation and Intracellular Ca
85
The Interface Between o2Adrenoceptors and Tyrosine Kinase Signalling Pathways
95
Differential Regulation of ozAdrenergic Receptor Subtypes by Norepinephrine
103
Molecular Basis of ozAdrenergic Receptor Subtype Regulation by Agonist
113
Adrenergic Receptor Subtypes Display Different Trafficking Itineraries
123
Differential
141
Clinical Applications of 0 2Adrenergic Agonists in the Perioperative Period
161
Therapeutic Use of 0 2Adrenoceptor Agonists in Glaucoma
179
ASPET COLLOQUIA
195
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