This book undertakes to cover all angles of current research in [actual symbol not reproducible] receptors, each chapter being written by a leader in the field. Starting with an excellent overview of the subject, it provides insights into ligand binding and the effects of site-directed mutagenesis; the transfer of the signal through the G-protein to various effectors and the internal cellular response; receptor trafficking; and the therapeutic implications of the receptors, with the effects of agonists and antagonists.
The scope of this volume makes it an indispensable guide for researchers working on any feature of [actual symbol not reproducible] receptors. It will also prove valuable to anyone with an interest in the structure and function of G-protein coupled receptors and the mechanisms by which they direct the response of the cell to multiple types of external stimuli.
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Structure and Mechanism
Delineating Ligandspecific Structural Changes in Adrenergic Receptors
Characterization of Stereoselective Interactions of Catecholamines with
Regulating Signal Transfer from Receptor to Gprotein
Caveolin an Integral Membrane Protein Component of Caveolae Membranes
Molecular Determinants of AgonistIndependent Activity in Adrenergic Receptors
Adrenergic Receptor Activation and Intracellular Ca
The Interface Between o2Adrenoceptors and Tyrosine Kinase Signalling Pathways
Differential Regulation of ozAdrenergic Receptor Subtypes by Norepinephrine
Molecular Basis of ozAdrenergic Receptor Subtype Regulation by Agonist
Adrenergic Receptor Subtypes Display Different Trafficking Itineraries
Clinical Applications of 0 2Adrenergic Agonists in the Perioperative Period
Therapeutic Use of 0 2Adrenoceptor Agonists in Glaucoma
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adenylyl cyclase adrenergic receptor adrenoceptors affinity agonist-promoted amino acids antagonists antibodies artery assay basolateral Biochem Biol brimonidine buffer Bylund catecholamines caveolae caveolin cell line Chem CHO cells clinical clonidine Cloning conformational decrease depression desensitization dexmedetomidine domains downregulation Eason effects expression Figure fluorescence function G protein G-protein coupled receptors gene glaucoma GT1 cells Hieble human hypotensive IANBD idazoxan immunoreactivity inhibition interaction kinase Kobilka labeled Lanier Lefkowitz ligand Liggett Limbird Lisanti mediated molecular molecules mutation Naunyn-Schmiedeberg's Arch Neubig neurons norepinephrine ocular oz agonists oz receptor oz-adrenergic receptor oz-adrenoceptor oz-AR ozA-AR-immunoreactive ozAR subtypes p-aminoclonidine peptide pertussis toxin Pharmacol phosphorylation plasma membrane platelet prazosin protein coupled receptors rabbit radioligand rauwolscine receptor activation receptor subtypes Regan regulation residues response Ruffolo Samama Sargiacomo sequence serine signal transduction specific stimulation structures studies subunit third intracellular loop tissues transfected transmembrane helix vivo yohimbine