Alzheimer's Disease: Methods and Protocols

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Nigel M. Hooper
Springer Science & Business Media, 2000 - Medical - 408 pages
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With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today, s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge

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Introduction to Alzheimers Disease David Allsop 1 Introduction
The Genetics of Alzheimers Disease Nick Brindle and Peter St GeorgeHyslop
Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimers Disease David S Knopman
Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein APP sAPPα Steven W Barger 1 Introduction
Quantifying Aβ140 and Aβ142 Using SandwichELISA Daniel M Skovronsky Jun Wang Virginia MY Lee and Robert W Doms
Electrophoretic Separation and Immunoblotting of Aβ140 and Aβ142 Matthias Staufenbiel and Paolo A Paganetti 1 Introduction
AβInduced Proinflammatory Cytokine Release from Differentiated Human THP1 Monocytes Kurt R Brunden June KocsisAngle Paula Embury and S...
Effects of the βAmyloid Peptide on Membrane Ion Permeability Hugh A Pearson 1 Introduction
Using γSecretase Inhibitors to Distinguish the Generation of the Aβ Peptides Terminating at Val40 and Ala42 Paolo A Paganetti and Matthias Staufen...
Designing Animal Models of Alzheimers Disease with Amyloid Precursor Protein APPTransgenes Jeanne F Loring 1 Introduction
Phosphorylation of Amyloid Precursor Protein APP Family Proteins Toshiharu Suzuki Kanae Ando Koichi Iijima Shinobu Oguchi and Shizu Takeda
Determining the Transmembrane Topology of the Presenilins GopalThinakaran and Andrew Doan 1 Introduction
Normal Proteolytic Processing of the Presenilins Henrike Hartmann and Bruce AYankner 1 Introduction
Apoptotic Proteolytic Cleavage of the Presenilins by Caspases TaeWan Kim 1 Introduction
The Phosphorylation of Presenilin Proteins Jochen Walter 1 Introduction
Interaction of the Presenilins with the Amyloid Precursor Protein APP Andreas Weidemann Krzysztof Paliga Ulrike Dürrwang Friedrich Reinhard Dai ...

Analysis of βAmyloid Peptide Degradation In Vitro Barbara Cordell and Asha Naidu 1 Introduction
Posttranslational Modifications of Amyloid Precursor Protein Ectodomain Phosphorylation and Sulfation Jochen Walter and Christian Haass
Posttranslational Modifications of the Amyloid Precursor Protein Glycosylation Chen LiuTomasz Rozmyslowicz Magda StworaWojczyk Boguslaw ...
Using an Amyloid Precursor Protein APP Reporter to Characterize αSecretase Susan Boseman Roberts 1 Introduction
Inhibition of αSecretase by Zinc Metalloproteinase Inhibitors S Parvathy Anthony JTurner and Nigel M Hooper 1 Introduction
Development of Neoepitope Antibodies Against the βSecretase Cleavage Site in the Amyloid Precursor Protein Carol W Gray and Eric H Karran 1 In...
βSecretase Tissue Culture Studies of Sequence Specificity Inhibitors and Candidate Enzymes Martin Citron
Distribution of Presenilins and Amyloid Precursor Protein APP in DetergentInsoluble Membrane Domains Edward T Parkin Anthony JTurner and Ni...
Characterization and Use of Monoclonal Antibodies to Tau and Paired Helical Filament Tau Peter Davies 1 Introduction
Tau Phosphorylation Both In Vitro and in Cells C Hugh Reynolds Graham M Gibb and Simon Lovestone 1 Introduction
TransglutaminaseCatalyzed Formation of AlzheimerLike Insoluble Complexes from Recombinant Tau Brian J Balin and Denah M Appelt 1 Introduct...

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