Alzheimer's Disease: A Compendium of Current Theories, Volume 924
Zaven S. Khachaturian, M.-Marsel Mesulam
New York Academy of Sciences, 2000 - Medical - 195 pages
Although Alzheimer's disease was formally described as a distinct clinical-neuropathological entity at the turn of the century, the intense research effort on this disorder was not mobilized until the 1970s. In the last 20 years, a rich array of new ideas on diagnosis, treatment, risk factors and possible cause(s) have emerged. The wealth of new information has led to the formulation of many current theories. However, little attempt has been made to integrate the different ideas or to establish a coherent link among the distinct theories, which at times appear to be at odds with one another and/or with the available data.
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3-amyloid abnormalities accumulation activity Address for correspondence aging allele alterations Alzhe Alzheimer disease Alzheimer's disease amyloid precursor protein apoE apoE4 apolipoprotein apoptosis associated axonal beta beta-amyloid beta-amyloid peptides biochemical Biol blood flow Brain Res calcium calpain cascade caspase cathepsin cell death cellular Chem cholesterol clinical cognitive complex cortex cortical degeneration dementia deposition dysfunction effects estrogen evidence excitotoxicity extracellular formation function gene genetic genotype glucose hippocampal human hypothesis impairment increased induced inflammation interactions lesions Lewy bodies lipid loss lysosomal mechanisms membrane metabolism mitochondrial spiral models molecular molecules mutations myelination N.Y. Acad Natl neuritic Neurochem neurodegenerative diseases neurodegenerative disorders neurofibrillary tangles Neurology neuronal neuropathological neuroplasticity neuroprotective Neurosci NFTs normal O-synuclein onset oxidative stress pathogenesis pathogenic pathways patients phenotype plasticity presenilin primates prion Proc protease receptor reduced risk factors role senile plaques studies synaptic tau pathology tauopathies tion tissue transgenic transgenic mice TrkA vascular vitro vivo