Amino Acids, Peptides and Proteins, Volume 34
In an ever-increasing domain of activity, Amino Acids, Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Volume 34 provides a review of literature published during 2001. Comprising a comprehensive review of significant developments at this biology/chemistry interface, each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters, ranging from current trends in their synthesis and conformational and structural analysis, to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters, whilst periodic chapters on metal complexes of amino acids, peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas, allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia will find this an indispensable reference source. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
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and Methods of Combinatorial Synthesis
A List of Syntheses in 2001
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acid residues Acta active site activity Albericio amide amino acids analogues antagonists antibiotic binding Biochem Biol Bioorg Biophys calpain carboxyl caspases catalytic cell Chem Chen chiral CO2H CO2Me complex compounds conformation conjugates copyright 2001 coupling cyclic peptides cyclo cysteine dark grey derivatives dimeric dipeptide disulfide disulfide bond domain enzyme ester Eur.J.Biochem Figure Fmoc fragment glycopeptide glycosylation helical HIV-1 PR human hydrophobic IC50 values inhibition integrin interactions ligands light grey linker loop Macmillan Magazines Ltd macrocyclic medium grey membrane mimetics moiety molecular molecule mutant N-terminal novel Pept Peptides containing peptidomimetic Perkin Trans potent inhibitor precursor protease proteasome protein proteinase reaction Reagents receptor Reproduced with permission resin ring role Scheme selective sequence showed shown side chain Solid-Phase Synthesis somatostatin spectroscopy SPPS studies substrate subunits Tetrahedron Lett thrombin tion vancomycin Wang X-ray Zhang