Amylin: Physiology and Pharmacology

Front Cover
Gulf Professional Publishing, 2005 - Medical - 341 pages
0 Reviews
Amylin deciphers amylin's physiology and reveals previously unrecognized mechanisms fundamental to control body weight and fuel homeostasis. This book also discusses therapeutic utility of amylin as the first new medicine to treat diabetes since insulin.

  • Provides a current comprehensive treatment of amylin the hormone
  • Identifies the majority of amylin's physiologic functions
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Tissue Expression and Secretion of Amylin
19
Receptor Pharmacology
47
Amylin and the Integrated Control of Nutrient Influx
67
Inhibition of Food Intake
79
Inhibition of Gastric Emptying
99
Effects on Digestive Secretions
123
Pancreatic Enzyme Secretion
131
Effects of Amylin on Gallbladder Contraction
138
Na+K Atpase in Muscle
223
Effects in Liver
229
Effects in
235
Effects of Amylin in Specific Vascular Beds
243
Pharmacology of Vascular Effect
245
Direct Inotropic Effects
246
References
248
Renal Effects Andrew Young I Summary
251

Effects of Amylin on Intestinal Glucose Transport
141
References
143
Inhibition of Glucagon Secretion Andrew Young I Summary
151
Glucagon Secretion in Insulinopenic Diabetes
154
Effects of Amylin on Glucagon Release from Isolated Preparations
155
Effects of Amylin in WholeAnimal Preparations
160
Pharmacology of Glucagonostatic Effect
166
Clinical Studies
167
Inhibition of Insulin Secretion Andrew Young I Summary
173
Background
174
Effects of Amylin on Insulin Secretion
175
Pharmacology of Insulinostatic Effect
182
Localization of Effects on Insulin Secretion
185
References
186
Effects on Plasma Glucose and Lactate Andrew Young I Summary
193
Plasma Lactate Concentration
194
Plasma Glucose Concentration
200
Timing of Changes
202
Mechanisms Linking Changes in Glucose and Lactate
203
Postprandial Glucose
205
References
206
Summary
209
Renovascular Effects
252
Effects on the ReninAngiotensinAldosterone System
253
Effects on Kidney Fluid and Electrolyte Excretion
256
Effects on Plasma Electrolyte Concentrations
258
Effects in Isolated Kidney Preparations
261
Effects on Subfornical Organ and Drinking Behavior
262
References
263
Effects on Bone Andrew Young I Summary
269
Effects on Calcium Concentrations
271
Effects on Osteoclasts
273
Effects on Osteoblasts
275
Effects in Models of Diabetic Osteopenia
276
Effects in Models of Osteoporosis
277
Central Nervous System and Other Effects Andrew Young I Summary
281
Effects on Amino Acid Transport
282
Effects on Memory
283
Effects on Locomotor Activity Grooming and Stereotypy
284
Effects on Body Weight
303
Index
322
Contents of Previous Volume
329
Copyright

Common terms and phrases

Bibliographic information