George G. Glenner
Springer US, Jun 1, 1986 - Medical - 858 pages
From a process that from the days of Vir chow and Rokitansky, primarily stimulated the relatively narrow interest of pathologists, amyloidosis has risen full-blown as one of the most important of disease complexes. Its presence dominat:es the lesions of Alzheimer's disease, a disease affecting an estimated 2. 5 million people in the U. S. A. and thereby closely rivaling stroke as the third most common cause of death. If, as it has been de scribed, Alzheimer's disease is the "Disease of the Century," then amy loidosis is the Disease Complex of the Ages. It affects in one or more of its manifestations every organ of the body, and is at least as old as the afflicted Egyptian mummies of the pyramids. With an increasing percentage of older individuals amyloid of the senior population becomes increasingly more frequent. The subjects covered in this Symposium range through almost every clinical medical specialty. From an average of one paper in each of the past three Symposiums, the explosive interest in cerebral amyloidosis has led to the presentation of 12 papers on this subject in the present volume. The genetically predisposed familial amyloidotic processes, such as the polyneuropathies and familial Mediterranean fever have also stimulated ex tensive and intriguing investigations which have revealed the striking effect of a single amino acid substitution in transforming a normal protein into. a lethal "amyloidogenic" one.
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Protein AA and Associated Proteins in TypeAA Amyloid
Heterogeneity of Human Amyloid Protein AA and SAA
Vascular AA Amyloidosis is Characterized by Special Protein
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A. S. Cohen AA protein Acad acute phase albumin Alzheimer's disease amino acid amino acid sequence amyloid deposits amyloid fibril protein amyloid fibrils amyloid protein amyloidosis amyloidotic analysis antibodies antigenic antisera antiserum Arthritis azocasein Bence Jones protein Biochem biopsy cardiac casein CBA/J cells Clin clinical colchicine component concentration Congo red Congo red staining cores detected E. C. Franklin electrophoresis eluted enzymes familial familial amyloid polyneuropathy FAP patients fractions G. G. Glenner Husby immunoglobulin Immunol injection isolated J. B. Natvig kidney light chains liver macrophages Medicine method mice molecular weight monoclonal mouse murine neurites peak peptides plasma polyneuropathy position prealbumin prealbumin variant present Proc protein AA proteinuria purified reaction renal residues SAA levels SAAL Scand scrapie SDS-PAGE senile plaques sera Shirahama showed Sletten spleen structure studies syndrome systemic amyloidosis Table tion tissue Westermark