An Introduction to Clinical Pharmaceutics
Although a knowledge of pharmaceutics (physical chemistry applied to pharmaceuticals) is essential in the design and manufacture of modern pharmaceutical dosage forms, a knowledge of the interaction of dosage forms with the body (clinical pharmaceutics) is essential for the practicing pharmacist. This textbook will thus describe a variety of dosage forms and their clinical importance and use. The use and behavior of dosage forms in different age groups and patient groups will also be considered along with recent developments such as personalized therapies and genomics. All of the principles underpinning clinical pharmaceutics will be described using relevant examples from the recent literature and clinical case studies.
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1 What is clinical pharmaceutics?
2 Excipients Not always inert
3 Thinking chemically
4 Looking at formulations
5 Adverse events and formulations and devices
absorption aciclovir acid active adhesion administration adverse events adverse reactions agents allergic amphotericin aqueous bacterial bioavailability bioequivalent biological branded capsules carrier catheters cause cells CF3 CF3 CH 3 CH chemical chemistry chloride ciclosporin clinical complex compound concentrations contact dermatitis contain Cremophor Cremophor EL Cross-reactivity DEHP delivery systems devices Diprivan dosage forms dose forms doxorubicin drug delivery dyes effects etoposide example excipients formulations glycol H H H hyaluronate hydrophilic hydrophobic impurities infusion injection insulin interactions intravenous lipid liposomes liquid manufacturing medication membrane mg/mL molecular weight molecules nanoparticles oesophageal OH OH oral paclitaxel paediatric particles patches patients pegylated peptide personalised medicines Pharm pharmaceutics pharmacokinetics pharmacy plasma poloxamer polymer polysorbate 80 pravastatin precipitation problems properties propofol proteins reference release rheology sevoflurane skin sodium solubilise solubility solution statins stent structure sulfate surface tension surfactants tablets talc tear film therapeutic therapy tissue toxicity transdermal vancomycin viscosity vivo